Studies Found: 32
Anger in Later Life
Do you ever wonder why other people have trouble managing their anger? Do you think anger is bad for your health? Can it ever be productive? How do you feel when another person is angry with you? These are just some of the questions Dr. Amanda Barusch is asking people over 50 years old in connection with this study.
If you are over 50, Dr. Barusch would love to talk with you about your experiences of anger. It doesn't matter whether you never get angry or you're angry all the time. She's hoping to learn about the wide range of experiences.
These conversations take about an hour, and are conducted via phone or zoom. They are entirely confidential and most people find them both interesting and enjoyable.
AT100-01: An AAV8 Neutralizing Antibody Seroprevalence Study in Subjects with Late Onset Pompe Disease
Patients with Pompe disease on a stable enzyme replacement therapy or naive to treatment are invited to come to clinic for a one time visit. This visit will include review of medical records and a blood draw to determine if you have antibodies against AAV8.
Benefit of Focused Ultrasound Treatment of Essential Tremor to Individuals With Vocal Tremor
The purpose of this study is to determine whether individuals being treated for their essential tremor significantly impairing hand/arm function also experience benefit to their voice tremor. This study will evaluate pre-treatment and post-treatment changes to voice tremor using clinical questionnaires, observation of tremor in structures of the face, jaw, tongue, and throat as well as using audio recordings and patient self-report. Individuals previously seen in the Voice Disorders Center where recordings of their throat were saved, post-FUS recordings can be made 3 months after treatment is completed if participants express interest in this option.
Brain Effects of CBD and THC
How do cannabis products such as CBD and THC affect brain function involved in attention, behavior, emotion, and cognition? Why do CBD and THC have different effects on individuals? Answering these questions may help many patients seeking cannabis related therapies.
This is where you come in. We need volunteers to receive various combinations of CBD, THC, and a placebo while undergoing MRI brain scans.
Five 3-hour appointments
Visits will consist of blood draws, urine samples, neuropsychological tests, MRI brain scans, and oral administration of CBD/THC products
Participants must provide someone to drive them home after visits 2-5
Whats in it for you?
Report from MRI brain scan and pictures of your brain
Contributing to a better understanding of the effects of cannabinoids in the brain
Compensation for study participation
Are you eligible?
No neurological or psychological disorder
No tobacco use (last 60 days)
No marijuana use (last 30 days)
No illicit drugs/opioids (last 60 days or history of dependency or abuse)
Females cannot be pregnant
Take the eligibility survey today!
Consumer Decision Making
This study is designed to understand the day-to-day decisions made by consumers.
COVID-19 Plasma study to limit complications from coronavirus
This research is being done to develop a possible new therapy for prevention and treatment of coronavirus disease (COVID-19).We would like to study whether human plasma containing antibodies to the SARS- CoV-2 virus could be an option for prevention and treatment of COVID-19. This type of treatment, known as passive antibody therapy, could be a way of rapidly treating patients when there are sufficient numbers of people who have recovered from infection and can donate antibody-containing plasma. We hope that it will either prevent illness caused by coronavirus or lessen the severity of symptoms.
COVID-19 Plasma-4 Study
This study is designed to test whether administration of plasma containing antibodies to people infected with the SARS-CoV-2 virus is able to prevent disease progression or lessen the severity of disease. We have collected plasma from people who have high levels of these antibodies because they have recovered from COVID-19. We will transfuse this high-antibody plasma into one group of infected people, and transfuse the other group of people with regular plasma that does not contain high levels of antibodies to COVID-19. We want to see if the COVID-19 antibody-containing plasma helps prevent the progression of infection or lessens the severity of current symptoms. In order to test this, we need to two groups of people in this study: Those receiving COVID-19 plasma and those receiving regular plasma without COVID-19 antibodies. Neither the participants nor the research team will know which type of plasma you receive.
Elucidating Brainstem Contributions to Visceral and Somatic Motor Dysfunction after mTBI
Optimal rehabilitative care following mild traumatic brain injury (mTBI) should be based on approaches that target the key underlying mechanism of dysfunction. However, the underpinnings of motor problems after mTBI, including imbalance and improper regulation of heart rate and blood pressure, remain unclear. This project will use state-of-the-art neuroimaging methods and detailed testing of motor function to examine the role of the brainstem in motor problems to better guide care in people with mTBI. Participants will have an MRI brain scan and complete several tests of mobility, cardiovascular, and pupillary function at two visits, separated three months apart.
Evaluation of Sensory Tricks in Individuals with Laryngeal Dystonia or Essential Vocal Tremor
Laryngeal dystonia (LD) is a rare neurogenic voice disorder that results in an intermittently strained-strangled or breathy voice quality during speaking. Essential tremor of the voice (ETv) is another neurogenic voice disorder typically perceived as a shaky voice quality but sometimes associated with a similar voice quality to LD, making it challenging for clinicians to distinguish these voice disorders. A correct diagnosis is essential for accurate and effective treatment of these voice disorders. However, clinical voice experts often confuse these disorders and frequently disagree with each other when judging voice quality or observing speech structures. Development of clinical tools that help clinicians make the correct diagnosis of these disorders is a priority. Therefore, we propose studying a characteristic of dystonias, sensory tricks. A sensory trick is a phenomenon diagnostic of dystonias described as a short-term improvement of symptoms due to sensory cues like touching or supporting a body part or being distracted by a sound. This phenomenon is well studied in other kinds of dystonia but has not been systematically evaluated in LD. This pilot study aims to evaluate whether sensory tricks improve voice symptoms in those with LD compared to those with ETv. If successful, outcomes will help identify specific sensory trick(s) that most clearly change LD symptoms and show promise for improving correct diagnosis of those with LD. The sensory tricks studied should be accessible and affordable for use during assessment by clinicians to help distinguish those with LD from ETv. Importantly, findings will inform future studies to improve utilization by clinicians.
Exploration of identity development and experiences of queer and transgender racial-ethnic minority young adults in Utah
The purpose of the study is to see how queer and trans young adults of color (racial-ethnic minorities) think about and talk about their sense of who they are. We hope that through better understanding the experiences of young adults who identify with these groups we may be able to provide recommendations for future research, for mental health professionals, and for higher education school administrators
For Vascular Surgery Patients who need upper arm brachial-basilic arteriovenous fistula (BBAVF) surgery
The purpose of this study is to help researchers to learn more about the surgical outcomes of each type of procedure and to understand the patients perspective after having had one of these two procedures. We hope that in the future we may be able to incorporate the patients perspective in the discussion of treatment options before surgery.
Adult patients who qualify to join this research study get dialysis treatment now. You may qualify if you need a surgery which requires a qualified surgeon to make in your arm a brachial-basilic arteriovenous fistula (BBAVF) using your own blood vessels (arteries and veins). This BBAVF procedure is done in either one stage or in two stages. The one stage procedure is completed in one surgery while the two stage procedure has two different surgeries about 6 to 8 weeks apart. There are no other differences from the standard fistula creation surgery.
GT-031: Study Evaluating the Efficacy and Safety of Belapectin (GR-MD-02) for the Prevention of Esophageal Varices in NASH Cirrhosis
The purpose of this study is to find out about the safety and efficacy of Belapectin (GR-MD-002) for the prevention of esophageal varices in NASH (Non-Alcoholic Steatohepatitis) Cirrhosis.
Belapectin is an investigational drug that has not been approved by Health Authorities in any country of the world, including the United States Food and Drug Administration (U.S. FDA). Belapectin (GR-MD-02) is a complex carbohydrate drug that targets galectin-3, a critical protein in the pathogenesis (the origin and development of the disease) of fatty liver disease and fibrosis. The drug binds to galectin and disrupts its function. Preclinical data in animals have shown that Belapectin has robust treatment effects in reversing liver fibrosis and cirrhosis.
Belapectin has been studied in clinical trials in patients with NASH cirrhosis and showed some evidence of potentially reducing the blood pressure in vessels entering cirrhotic liver and preventing the development of new esophageal varices (Enlarged veins). The esophagus is a muscular tube connecting the throat (pharynx) with the stomach and carries food and liquids to the stomach. The development of esophageal varices is one of the complications of cirrhosis and can cause unexpected and often severe bleeding in the digestive system.
How COVID-19 has Impacted Secondary School Aged Students with Autism
The purpose of this study is to explore the academic, psychological and social experiences of secondary school aged individuals with an autism spectrum disorder during COVID-19.
Immune Responses to COVID-19
We are interested in learning more about how people respond to COVID-19 infection, and in particular how people develop and maintain immunity against this viral infection. We are recruiting people who have recovered from COVID-19 and asking them to donate blood to our laboratory and complete a health history form. This will help us compare the clinical course people experienced with the responses their bodies generated against the virus. We will likely perform these blood draws and questionnaires several times over a two year period, which will help us understand if people maintain immunity against the virus in the long-term.
Janssen COVID-19 Vaccine Study
This Phase 3 clinical study will assess the effectiveness of a novel COVID-19 vaccine. It includes a placebo such that half the participants will receive active COVID vaccine and half will receive placebo. Study participants will provide written informed consent, then they will be vaccinated and followed for one year.
Learning New Movements Across the Lifespan
The goal of this research is to provide a comprehensive investigation into how novel movements are learned and subsequently stored into long-term memory across the human lifespan.
LevoCept IUD - Phase III
The LevoCept IUD is an investigational product that is being developed as a possible method of birth control. The LevoCept IUD (when inserted into the uterus) releases the birth control hormone, levonorgestrel. This method of birth control is similar to that used by currently approved hormonal IUDs including MIRENA®, LILETTA® , and SKYLA®. By contrast, the LevoCept IUD is made of a more flexible material with a spring-type shape, which conforms to the shape of your uterus with the goal of providing comfort during device insertion.
The purpose of this study is to find out:
If LevoCept is effective in preventing pregnancy
How easy LevoCept is to put in your uterus
If there are any effects of LevoCept on menstrual periods and bleeding
The ability to become pregnant within a year after LevoCept is removed for those who decide to leave the study early to become pregnant
How women tolerate LevoCept
If there are safety issues associated with LevoCept
The purpose of the study is to evaluate if the long-term intake of the new drug, called lucerastat, is safe and well-tolerated in adults with Fabry disease.You have been asked to take part because you have Fabry disease and have completed the MODIFY study. Fabry disease is a rare, inherited disease caused by a genetic fault (mutation) which leads to a harmful accumulation of fatty substances in the body. This can cause symptoms of pain such as a burning feeling, shocks or shooting pain, tingling, pins, and needles, stabbing or numbness in hands and feet. It can also cause stomach symptoms like diarrhea and stomach pain. Fabry disease can also cause damage to vital organs like the heart, kidney, and brain.
This brain imaging study will enroll healthy participants in order to compare brain function measures to a separate group of individuals with depression.
NERVE TRANSFERS TO IMPROVE UPPER EXTREMITY FUNCTION AND QUALITY OF LIFE IN TETRAPLEGIC PATIENTS
The purpose of this study is to gather information about the treatment of Spinal Cord Injury (SCI) through the use of a surgical procedure known as a nerve transfer.
SCI is a devastating condition which is thought to affect nearly 40 cases per million persons annually in the US. More than 50% SCI occur in the cervical spine (i.e., tetraplegia), resulting in some loss of arm and/or hand function.
Nerve transfers are used to improve upper extremity and hand function in patients who have suffered from SCI. This is a treatment option that is available to all (appropriate) patients, and participation in this study is not necessary to receive this treatment.
Participation in this study is voluntary, and is available only to those who meet certain eligibility criteria. These criteria will be reviewed on a case by case basis by the University of Utah Department of Neurosurgery's study team as potential participants express their interest in the study. Various appointments and/or diagnostic procedures may be scheduled in order to ensure the eligibility of potential patients.
There is no financial cost to patients (aside from the standard costs of care) who participate in this study, and there are no direct financial benefits provided for doing so. Participants will be followed after the procedure both by the surgeon and the physical therapy team. This study does provide funding for the physical therapy services utilized in the long-term follow up phase, but this funding is limited. So participants are encouraged to schedule these visits appropriately.
The information provided on this page is not exhaustive, so those who are interested in this study are encouraged to contact our study team to discuss any questions they might have. You can do this by contacting the study coordinator, Kirby Taylor, via telephone or email.
Neurofibromatosis Type 1 and Vitamin D Supplementation
This is a randomized clinical trial of oral vitamin D therapy in adults with NF1 and vitamin D insufficiency. We are looking for about 320 adults with known NF1 to participate in this study. The purpose of this study is to treat adults with two different doses of vitamin D to determine which dose is most appropriate to maintain bone mineral density of the spine and hip.
NeXXstep Study (infant pneumonia vaccine)
Your baby may be eligible to take part in this research study if your baby is healthy, about 2 months old, and has not been previously vaccinated with any pneumococcal vaccine. The purpose of this study is to see if an experimental vaccine can prevent serious infections due to a germ called Streptococcus pneumoniae. These types of germs can lead to pneumonia and other types of respiratory infections.
pheNIX clinical study
The study will include a screening to make sure participants are healthy and are able to enroll in the study and receive a single administration of HMI-102, an investigational gene therapy for the treatment of adults with PKU.
Following a single administration of HMI-102, participants will be observed periodically for 52 weeks to see if the gene therapy is helping the participant make their own PAH enzyme.
Finally, participants will be seen less frequently for another four years to make sure that the new gene therapy is restoring active PAH enzyme activity to cells.
Positive psychological change experienced by couples facing a diagnosis of life-limiting cancer
This study will examine how couples cope with the diagnosis of advanced cancer. There is currently not enough research regarding psychological wellbeing among couples coping with the diagnosis of advanced cancer. This limits our ability to provide services and programs to better support these couples. This study seeks to examine the experiences of all types of couples (cisgender, heterosexual couples, and LGBTQ+ couples) to better understand if there are unique ways that couples cope with the stress associated with a cancer diagnosis. Previous research has not included LGBTQ+ couples, so it is unknown if there are specific needs that this population may have. The information gained from this study will help to inform future programs and services designed to support all couples through the diagnosis of life-limiting cancer.
RECOVER Study: COVID-19 infection and illness rates in Essential Workers
This study is a multi-site prospective study focusing on SARS-CoV-2, or COVID-19, infections among essential workers (EW). EW are at high-risk because they are on the front lines of the COVID-19 pandemic. Further research is needed in order to help identify occupational groups that may be more vulnerable within EW. This study is voluntary, meaning you decide whether or not you want to participate. The purpose of this study is to understand the risks of infection and the immune response against SARS-CoV-2, the virus that causes COVID-19.
ReNu: Neurofibromatosis Type 1 (NF1) Plexiform Neurofibromas trial
The purpose of this study is to determine the effectiveness of the study drug at improving a plexiform neurofibroma (PN) that is causing significant issues in people with neurofibromatosis Type 1 (NF1). This study is for people 2 years of age and older
School Psychology Services and Stress Among Caregivers During COVID-19.
The purpose of the study is to find out what type of telehealth (live videos, phone calls, emails, mobile apps, webpages, or adaptive and assistive equipment) and services (IEP related services, counseling, consultation, assessments, behavior strategies) families received from their local school psychologist during COVID-19. The study will also analyze student's caregiver perceived levels of stress during the pandemic.
The results of this study will provide needed information regarding how to better support students and their families during emergencies.
Social support needs and networks of cancer survivors and caregivers during COVID-19 pandemic
Cancer survivors and their care partners often turn toward their social networks for help and support, but the COVID-19 pandemic can make this difficult. Access to clinical care and support services may be limited. Social distancing may change the nature and timing of regular social interactions, making it harder to get support from their usual network of family and friends. Our study team wants to better understand survivors and caregivers social support needs, networks, and interactions during the pandemic, and how these connect with stress and wellbeing. This will help us develop strategies for improving or maintaining social support and wellbeing during crises, and beyond. We are enrolling cancer survivors who received at least one cancer diagnosis in the past 5 years and who have a care partner or close support person who is also willing to participate. Both participants must be 18 years old or better. All study activities are completed online or by phone, so no travel or in-person contact is required. Participants will receive up to $150 in gift cards for completing the study.
Students' Goal and Priority-Setting related to Relationship Abuse
We are looking to hear from students at the University of Utah about their experiences with relationship abuse. Specifically, we are interested in what goals and priorities are important to them.
Using Mindfulness Techniques to Treat Chronic Pain and Reduce Opioid Use
In this study, we will teach participants mindfulness techniques to help them cope with chronic lower back pain. You must be at least 18 years of age with a diagnosis of lower back pain and taking a prescription opioid medication to participate. Those who choose to enroll will participate in 4 weeks of group therapy (30 minutes per week) group sessions led by a masters-level therapist and prescribed daily at-home mindfulness practice. Participants will be evaluated using interviews and surveys before, after, and during the group therapy intervention.
Using neuroimaging to predict chronic pain and medication use
Chronic pain impacts one in every five people in the United States. In this study, we are using brain imaging technologies to better understand chronic pain and to help inform future efforts to develop more effective, personalized treatment strategies for people affected by chronic pain. Specifically, we are interested in seeing whether measures of brain activity can predict future pain and pain medication use. For this study, we are recruiting individuals who are willing to be scanned using functional MRI and to fill out monthly surveys over 6 months.
Vertex VX-864 in PiZZ Subjects
We are looking for adults between the ages of 18 and 80 with Alpha-1 Antitrypsin Deficiency to participate in this clinical research study. The purpose of this study is to evaluate the safety, tolerability, and effectiveness of an investigational medication in individuals with Alpha-1 Antitrypsin Deficiency. The word investigational means this medication is not yet approved for use by the Food and Drug Administration (FDA)
in the United States or other regulatory agencies in Canada, Europe, or elsewhere.
Interested individuals will be evaluated during a screening period to determine their eligibility to participate. Your participation could last approximately 1318 weeks depending on whether or not you have ever been on augmentation therapy. Those who qualify will receive all study-related medications and procedures at no cost.
You may also be compensated financially for your study-related time and travel.