Study Locator
12-week, Randomized, Double-blind, Placebo-controlled Study Investigating the Efficacy of AMT-101 in Subjects with Chronic Antibiotic-resistant Pouchitis
12-week, Randomized, Double-blind, Placebo-controlled Study Investigating the Efficacy of AMT-101 in Subjects with Chronic Antibiotic-resistant Pouchitis (IRB#: IRB_00135399)
165-306: Pegvaliase in adolescents with Phenylketonuria (PKU)
The purpose of this study is to learn more about how the medication called pegvaliase works in people with PKU. This study will help us learn if pegvaliase combined with special Phe-restricted diet (also called a PKU diet) is safe and better than the special Phe-restricted diet alone for controlling blood Phe levels in adolescents. (IRB#: IRB_00155863)
4D-310-C001: An Open-Label, Phase 1/2 Trial of Gene Therapy 4d-310 In Adult Males With Classic Fabry Disease
This is a Fabry disease study aimed to test a new gene therapy called 4D-310. This will be the first study in which 4D-310 will be tested in human patients and the purpose of this study is to find out the best dose of 4D-310 that is safe for use in patients with Fabry disease. (IRB#: IRB_00138626)
A Machine Learning Model as an Automatic Tool to Record Human Behavior
A machine learning model may automatically record a human's challenging behavior. Research is needed to learn the value of the model. We want to learn three specific things. 1) How well the model can track challenging behavior? 2) Can the model produce new information based on previous training? 3) How accurate and reliable the model can track challenging behavior based on the new information? The information we gain may aid future patients (IRB#: IRB_00157027)
A Smartphone Healthcare Tool for People who live in Urban and Rural Utah
COVID-19 brought focus to racial and ethnic inequalities, including people with low income, and in rural communities. Research is needed to understand how a smartphone tool can be most helpful for healthcare testing such as COVID-19. We may also learn how people can use the tool for other health issues. The information gained will aid future patients. (IRB#: IRB_00151156)
A Study to Help People Quit Smoking
Tobacco use is the leading cause of death and disability in the U.S. that is preventable. Just-In-Time is a tool developed for preventing and treating addictions. Research is needed to know the effectiveness of the tool. The information we learn may aid future patients. (IRB#: IRB_00112287)
A study to see if doctors can use and work a nasal swab test into their workflows
The purpose of this study is to introduce physicians to a genomic test, called the Percepta Nasal Swab, and to assess the ability of the test to be integrated into physicians patient care plans and workflows. The sponsor wants to eventually determine if the Percepta Nasal Swab test is useful in determining the risk of lung cancer when a lung nodule has been detected. This study is an early step in this overall goal. Information from this study will be used in doing other future studies that will determine its usefulness. (IRB#: IRB_00150725)
A Study to Test the iDOSE Computer Program with the IFX Drug for People with Crohns Disease
Crohns disease (CD) can cause many constant health issues such as severe stomach pain. IFX is a drug to help people with symptoms. iDOSE is a computer program that may guide doctors and patients with CD to know the right amount of IFX to take for better health. Research is needed to learn the effectiveness of using iDOSE. The information we learn may aid future patients. (IRB#: IRB_00153856)
ABBV-154: A Study Drug to Improve Crohns Disease Symptoms
ABBV-154 is an anti-body study drug to help people with Crohn's disease reduce inflammation with fewer side effects. Scientists and doctors do not know the safety and effectiveness of ABBV-154. Research is needed to learn if it may be approved and used to improve the health of people with Crohn's disease. (IRB#: IRB_00150107)
ABBV-951: A Study Drug for People with Parkinson's Disease
Parkinsons disease (PD) causes nerve damage in the brain making it difficult for people to move. ABBV-951 is a study drug to help people with symptoms. Research is needed to learn the safety and effectiveness of the drug and how it reacts when it is given under the skin of a persons body. The information we learn may aid future patients. (IRB#: IRB_00153168)
Adolescent and Young Adults with SCN8A Randomized trial with placebo or NBI-921352
The purpose of this clinical research study is: to find out if the use of study drug NBI-921352 along with the current therapies you are already receiving can help with the treatment of SCN8A Developmental and Epileptic Encephalopathy Syndrome (SCN8A-DEE) by looking at how it affects things such as your symptoms, quality of life, severity of seizures and frequency of seizures. to assess the pharmacokinetics (how the body absorbs, distributes, and gets rid of the study drug of NBI-921352 and to determine its effect on the plasma levels of concomitant (other) antiseizure medications and evaluated metabolites. to evaluate the safety and tolerability of NBI-921352. (IRB#: IRB_00150547)
AFib Decision-Making Education
Atrial Fibrillation (AFib) is found in people with an irregular heartbeat. The condition causes a higher risk of stroke. There are choices people make with their doctor to address the issue. Research is needed to see if using educational websites helps patients make the best decision with their doctors. The information we learn will aid future patients. (IRB#: IRB_00124127)
Amniotic Fluid Epidural Injection for People with Low Back and Hip Pain caused by pressure on the Spinal Cord
Lumbosacral radicular pain is in the low back and hip caused by pressure on the spinal cord. The human amniotic fluid epidural injection is a new way to reduce this pain. Corticosteroid dexamethasone is the standard of care to improve symptoms. Research is needed to learn which is more effective at helping people with the condition. The information we learn will aid future patients. (IRB#: IRB_00131761)
APD334-210 Gladiator UC: A Randomized, Double-Blind, Placebo-Controlled, 52-Week Study to Assess the Efficacy and Safety of Etrasimod in Subjects with Moderately Active Ulcerative Colitis
A 52-Week Study to Assess the Efficacy and Safety of Etrasimod in Subjects with Moderately Active Ulcerative Colitis (IRB#: IRB_00145459)
Are you interested in starting a contraceptive gel for men?
The purpose of this study is: To develop a new form of contraception for men (IRB#: IRB_00143909)
Assess the Science to Stop Smoking
Tobacco is related to at least 20 different cancers. Most attempts to quit smoking fail. Technology has been developed to better understand how a persons emotions impact people in their efforts. Research is needed to assess the support people need to stop smoking. The information we learn may aid future patients. (IRB#: IRB_00104596)
AT100-01: An AAV8 Neutralizing Antibody Seroprevalence Study in Subjects with Late Onset Pompe Disease
Patients with Pompe disease on a stable enzyme replacement therapy or naive to treatment are invited to come to clinic for a one time visit. This visit will include review of medical records and a blood draw to determine if you have antibodies against AAV8. (IRB#: IRB_00131563)
BAX 111 rVWF in Pediatrics
The purpose of the study is to look at how well recombinant von Willebrand Factor (rVWF) (the study drug) works to control bleeding that is not caused by surgery. The study will involve children with severe von Willebrand disease (VWD), and we hope to learn how safe the study drug is and how well it is accepted. The study will also look at how safe the study drug is and how well it works during surgery. Finally, the study will look at how childrens bodies process the study drug. This is a Phase 3 study, which means the study drug has already been given to other patients in other studies. In a Phase 3 study the new drug is tested longer and on more people. (IRB#: IRB_00099444)
Behavioral micro-feature discovery using artificial intelligence
This study uses artificial intelligence technology to discover facial and vocal micro-features in individuals with and without depression. (IRB#: IRB_00135711)
Benefit of Focused Ultrasound Treatment of Essential Tremor to Individuals With Vocal Tremor
The purpose of this study is to determine whether individuals being treated for their essential tremor significantly impairing hand/arm function also experience benefit to their voice tremor. This study will evaluate pre-treatment and post-treatment changes to voice tremor using clinical questionnaires, observation of tremor in structures of the face, jaw, tongue, and throat as well as using audio recordings and patient self-report. Individuals previously seen in the Voice Disorders Center where recordings of their throat were saved, post-FUS recordings can be made 3 months or longer after treatment is completed if participants express interest in this option. (IRB#: IRB_00138236)
Benralizumab: A Study Drug for People with EGPA
Benralizumab is a study drug to reduce or remove white blood cells for people with Eosinophilic Granulomatosis with Polyangiitis (EGPA). Research is needed in the United States to confirm the safety and effectiveness of the drug so it may be approved and used to improve the health of people suffering from EGPA. (IRB#: IRB_00136755)
Bezafibrate and Obeticholic Acid: Study Drugs for People with Primary Biliary Cholangitis
Primary Biliary Cholangitis (PBC) is an autoimmune disease that causes liver damage and other severe health issues. Bezafibrate and Obeticholic are study drugs for adults with PBC. Research is needed to know the safety and effectiveness of the drugs combined and Bezafibrate alone. The information we learn may aid future patients. (IRB#: IRB_00151070)
BI 706321: A Study Drug for Patients with Crohn's Disease
Crohns disease (CD) can cause severe pain and swelling in a persons stomach. BI 706321 is a study drug to help people with this disease. Research is needed to know the safety and effectiveness of this drug combined with ustekinumab, an approved drug that stops painful symptoms. The information we learn will aid us in understanding how to best treat people with Crohns disease. (IRB#: IRB_00150629)
Boston Scientific Spinal Cord Stimulation (SCS) Systems in the Treatment of Chronic Low Back and/or Leg Pain with No Prior Surgeries.
The purpose of this study is to evaluate the safety and effectiveness of Spinal Cord Stimulation (SCS), when using a Boston Scientific WaveWriterTM SCS System with multiple modalities, as compared to Conventional Medical Management (CMM) in patients with chronic low back and/or leg pain, who have not undergone spinal surgery. The study will research the safety of the Boston Scientific WaveWriter SCS System and if it works to treat chronic low back pain and/or leg pain in patients who have not had a previous back surgery and if there are any side effects. WaveWriter Spinal Cord Stimulator Systems (also referred to as WaveWriter SCS Systems throughout this document) are FDA approved in the United States for commercial use in patients who have had a previous back surgery that failed to treat chronic pain (also known as failed back surgery syndrome), complex regional pain syndrome, and/or intractable (difficult) low back pain and/or leg pain. (IRB#: IRB_00140860)
Brain Effects of CBD and THC
How do cannabis products such as CBD and THC affect brain function involved in attention, behavior, emotion, and cognition? Why do CBD and THC have different effects on individuals? Answering these questions may help many patients seeking cannabis related therapies. This is where you come in. We need volunteers to receive various combinations of CBD, THC, and a placebo while undergoing MRI brain scans. Whats involved? Five 3-hour appointments Visits will consist of blood draws, urine samples, neuropsychological tests, MRI brain scans, and oral administration of CBD/THC products Participants must provide someone to drive them home after visits 2-5 Whats in it for you? Report from MRI brain scan and pictures of your brain Contributing to a better understanding of the effects of cannabinoids in the brain Compensation for study participation Are you eligible? No neurological or psychological disorder No tobacco use (last 60 days) No marijuana use (last 30 days) No illicit drugs/opioids (last 60 days or history of dependency or abuse) Females cannot be pregnant Take the eligibility survey today! https://is.gd/cbdstudy (IRB#: IRB_00127478)
Brain MRI scan of schizophrenia or schizoaffective patients vs. healthy controls
The purpose of the study is to gain an improved understanding of whether energy production in neurons is impaired or not. Neurons attempt to increase energy production via several mechanisms under hypoxia [low oxygen saturation in the bloodstream]. Energy production is mandatory for the survival and maintenance of ongoing cellular functions such as communications between neurons, the clearance of toxic products from cell, continuation of enzymatic reactions, ion transport in neurons etc. Phosphorus magnetic resonance spectroscopy (P-MRS) is a magnetic resonance imaging method which provides data regarding the concentrations of neuronal metabolites related to energy production. Our primary aim is to compare the concentrations of these substances before and after hypoxia challenge, which will enable us to comment on the dynamic change in energy production in neurons when higher energy is demanded. This study wishes to test this hypothesis in an effort to learn more about this mechanism, to assist the development of novel treatments for schizophrenia. In this study, we will also analyze certain blood molecules (polyamine and glutathione levels) which have been indirectly related to the receptor function and energy production in neurons, respectively. In brief, glutathione is a natural molecule which is used by neurons to neutralize the toxic by-products [reactive oxygen species, ROS] of energy production. The overproduction or impaired neutralization of reactive oxygen species can result in damage to DNA, proteins, lipid molecules in neurons and dampening of neuronal function. Receptors are located on the surface of neurons which mediates the communication between neurons mostly via molecules called neurotransmitters. Each neurotransmitter binds to the specific receptors assigned to certain neurotransmitters. NMDA [N-methyl-D-aspartate] is the receptor of interest in this study since an association between the impairment in NMDA receptor function and schizophrenia has been reported many times. Polyamines (putrescine, agmatine, spermine and spermidine) are molecules which modulates NMDA receptor function in different ways. Agmatine blocks NMDA function while spermine potentiates the function of these receptors. Putrescine and spermidine have no direct effects on NMDA receptors but they are intermediate molecules between agmatine and spermine. We are planning to compare baseline polyamine level in people with schizophrenia or schizoaffective disorder and healthy counterparts. (IRB#: IRB_00138477)
Breast Cancer Magnetic Resonance Imaging (MRI) Study
Breast cancer is the second most common cancer for women in America. Magnetic Resonance Imaging (MRI) can be used to see breast cancer. Research is needed to design better imaging techniques for breast cancer imaging. Information we gain may aid future patients. (IRB#: IRB_00114506)
Breathing Patterns of Infants
Feeding and communication problems may occur in infants. Research is needed to learn if infant breathing patterns provide early detection of these and other developmental challenges. (IRB#: IRB_00140651)
Cancer Stories Shaping Outcomes Can Your Cellphone Be a Compassionate Listener?
This study is looking at cancer patient voices, actions and body language using computer measurements of behavior via video-recorded answers to questions on your smartphone device using a free app. This research is important because it may help us discover and understand unknown factors that impact cancer treatment outcomes. (IRB#: IRB_00143135)
Cannabis (CBD) Effects of Treating People for Chronic Non-Cancer Pain
Cannabis (CBD) is a treatment shown to reduce non-cancer chronic pain. Research is needed to learn more about how CBD impacts brain chemistry. The information learned will help us better understand the effectiveness of CBD for improving the health of people suffering from chronic pain. (IRB#: IRB_00124865)
CAP-1002: A Study Drug for Human Allogeneic Cardioshere-Derived Cells for People with Duchenne Muscular Dystrophy (DMD)
Duchenne Muscular Dystrophy (DMD) is a disease that weakens people's muscles over time. CAP-1002 is a study drug to help people with this disease. Research is needed to learn the safety and effectiveness of the drug. This information we gain may aid future patients. (IRB#: IRB_00150933)
Caregiver burden associated with Rotavirus-gastroenteritis in the United States
You and your child are being invited to participate in this observational research study. Your participation is voluntary. An observational study is research that aims to collect data over time on how a certain treatment is used and its effects, without any change to your normal care. This means that routine clinical practice is followed. Any treatment given follows your normal routine and is decided by you and your doctor. This study will not alter or interfere with the normal care you receive in any way. (IRB#: IRB_00148762)
Celgene EoE
The purpose of this study is to see if CC-93538 is safe and effective as a possible treatment for EoE. To do this, a comparison will be made between subjects who receive CC-93538 and subjects who receive a placebo (a dummy treatment that looks like CC-93538 but contains no active ingredient). The purpose of this Phase 3 study is to help confirm the earlier results from a completed Phase 2 study, which suggests that CC-93538 may be safe and effective in treating patients with EoE. (IRB#: IRB_00140628)
Cervical Transforaminal Epidural Steroid Injection (TFESI): A Treatment for People with Cervical Radicular Pain
Cervical Radicular Pain is neck pain that goes into the shoulder and/or arm causing weak and numb muscles. This can cause severe back and joint pain, and depression. Cervical transforaminal epidural steroid injection (TFESI) may help people improve their symptoms. Research is needed to learn the effectiveness of TFESI. The information we learn will aid future patients. (IRB#: IRB_00116040)
Children and Adults with Eosinophilic Esophagitis (EoE), Gastritis (EG) and Colitis (EC)
EoE, EG, and EC are digestive diseases. Research is needed for us to understand the relationship of EoE, EG, and EC with mucosal eosinophilia, severe stomach, and bowel pain, in children and adults. The information we learn will help us find better ways to provide care for children and adults with these diseases. (IRB#: IRB_00113124)
Chronic Non-Cancer pain MRI research study evaluating the effects of oral cannabis on chronic pain
The purpose of the study is to evaluate the effects of two substances derived from cannabis (THC and CBD) in participants with chronic non-cancer pain compared with a placebo. The study drug will be administered as an extract mixed in chocolate pudding. Participants will be allowed to stay on their current pain treatments for the study but may not add any more medications during the study. Participation in this study will be confidential. This study has been approved by the FDA, DEA, and University of Utah IRB. (IRB#: IRB_00103451)
Chronic Wounds
The purpose of the study is to find out if human amniotic fluid can improve your chronic extremity wound, decreasing the inflammation and assisting the wound(s) to heal. Amniotic fluid is the liquid that surrounds the unborn, growing baby during pregnancy. Amniotic fluid is mainly water, but also has other components like proteins and antibodies that protect the baby from infection and help growth. Some of these components have been shown to have an anti-inflammatory effect. The fluid is obtained during the delivery of the baby and processed so that it is sterile and can be injected into wounds. (IRB#: IRB_00128708)
Compare the Study Drug Remibrutinib to an approved drug Teriflunomide for People with Relapsing Multiple Sclerosis (RMS)
MS is a long-lasting disease that can affect a persons brain and spinal cord. Teriflunomide is an approved drug to reduce relapsing MS (RMS). Remibrutinib is a study drug to reduce RMS. Research is needed to learn the safety and effectiveness of the study drug. While also seeing if it reduces RMS better than Teriflunomide. The information we learn will aid future patients. (IRB#: IRB_00152490)
Computerized Cognitive Remediation for Treatment Resistant Geriatric Depression
COVID-19 Study
The purpose of this study is to test how well depressed older adults are able to complete a computerized program designed to improve certain types of thinking skills (CCR-GD). We are also interested in whether participating in CCR-GD will improve both your thinking and mood. This research is being done because typical antidepressants are not fully effective and/or may be associated with cognitive deficits in many older adults with depression. This leaves them vulnerable to future depressive episodes. The development of new, non-invasive treatments that may help both mood and cognitive symptoms could potentially help older adults with depression. (IRB#: )
Computerized Cognitive Remediation for Treatment Resistant Geriatric Depression
The purpose of this study is to test how well depressed older adults are able to complete a computerized program designed to improve certain types of thinking skills (CCR-GD). We are also interested in whether participating in CCR-GD will improve both your thinking and mood. This research is being done because typical antidepressants are not fully effective and/or may be associated with cognitive deficits in many older adults with depression. This leaves them vulnerable to future depressive episodes. The development of new, non-invasive treatments that may help both mood and cognitive symptoms could potentially help older adults with depression. (IRB#: IRB_00103167)
Connecting Online Peers to Support Adults with Type 1 diabetes
Diabetes is a serious disease for millions of Americans. Self-management of the condition can be difficult. Social support shows people better manage the disease by working with peers. Connecting online peers is a way to help people with the disease. Research is needed to compare the effectiveness of online peer support groups for young adults with type 1 diabetes. (IRB#: IRB_00153324)
Consumer Decision Making
This study is designed to understand the day-to-day decisions made by consumers. (IRB#: IRB_00136063)
Cooled Radiofrequency to Standard Radiofrequency ablation for People Suffering from Chronic Low Back Pain
Long-term low back pain (LBP) is a common issue that affects many people causing poor overall health. There are two possible ways doctors may help people with LBP. One is Cooled Radiofrequency Ablation (CRFA). The other is Standard Radio Frequency Ablation (SRFA). Research is needed to learn which is better and reducing pain. The information we gain may aid future patients. (IRB#: IRB_00141224)
COVID-19 and Female College Students
COVID-19 Study
COVID 19 drastically changed the lives of all people, including female college students. Researchers want to learn the effect of COVID 19 and better understand what this population needs to succeed during a pandemic. (IRB#: IRB_00147067)
COVID-19 Vaccine Study
mRNA-1273 is a COVID-19 vaccine approved by the federal drug administration (FDA) for children 9 to 11 years old. Research shows that the COVID-19 vaccine can be taken with other vaccines. V503 is an HPV vaccine approved by the FDA for children 9-11 years old. HPV can cause certain cancers. Research is needed to learn more about the safety and effectiveness of taking the vaccines at the same time. The information we gain may aid future patients. (IRB#: IRB_00150880)
CSL-964
A study to evaluate the safety and efficacy of Alpha 1 Antitrypsin for the prevention of graft versus host disease in patients receiving hematopoietic cell transplant (IRB#: IRB_00125273)
CTL019: A Study Drug for Pediatric Patients with Recurring B-Cell Acute Lymphoblastic Leukemia (ALL)
Acute lymphoblastic leukemia (ALL) is the most common form of pediatric leukemia. CTLO19 is a study drug for children with recurring B-Cell ALL. Research is needed to learn the safety and effectiveness of the study drug. The information we gain may aid future patients. (IRB#: IRB_00078083)
Depression and Motor Function Study
This study will enroll participants with and without depression to study difference in motor functions between these groups, to understand if motor function predicts response to treatment, and to identify the brain regions involved in motor dysfunction in depression. (IRB#: IRB_00139658)
Does vaping cause lung injury?
This study is being done to increase what we know about lung disease caused by breathing in vapors from vape pens or e-cigs. (IRB#: IRB_00132574)
DTX401-CL301: Gene Therapy for Glycogen Storage Disease type Ia (GSDa1)
This research study will assess if DTX401 is a safe and effective treatment in patients with GSDIa. DTX401 is an experimental gene therapy product for GSDIa that aims to transfer working copies of the normal human G6PC gene to the liver through a one-time infusion into a vein. DTX401 is being developed with the goal of helping people with GSDIa maintain more normal blood sugar levels and have fewer episodes of hypoglycemia. (IRB#: IRB_00145310)
DUR-928: A Study Drug for People with Alcoholic Hepatitis
Alcoholic Hepatitis (AH) is a severe form of alcoholic liver disease (ALD). DUR-928 is a study drug to treat people with this condition. Research is needed to know the safety and effectiveness of the drug. The information learned will help us know if it may be used to provide better care for people with Alcoholic Hepatitis. (IRB#: IRB_00136308)
Effect of Levodopa on Blood Pressure and Heart Rate in People with Parkinson's Disease
Levodopa is the most common medication used to treat the symptoms of Parkinsons disease (PD). Research is needed for us to better understand how Levodopa affects blood pressure and heart rate. The information we learn will improve our knowledge of the medication to provide the best care for people with PD. (IRB#: IRB_00152581)
Effect of Transcranial Magnetic Stimulation (TMS) on the Brain with Emotions
Transcranial Magnetic Stimulation (TMS) is a safe way to help a persons brain. Research is needed to understand how the brain works when a person is emotional. The information we learn will help us know the impact repeated TMS over the front of the brain has on a persons emotions. (IRB#: IRB_00109039)
Elucidating Brainstem Contributions to Visceral and Somatic Motor Dysfunction after mTBI
Optimal rehabilitative care following mild traumatic brain injury (mTBI) should be based on approaches that target the key underlying mechanism of dysfunction. However, the underpinnings of motor problems after mTBI, including imbalance and improper regulation of heart rate and blood pressure, remain unclear. This project will use state-of-the-art neuroimaging methods and detailed testing of motor function to examine the role of the brainstem in motor problems to better guide care in people with mTBI. Participants will have an MRI brain scan and complete several tests of mobility, cardiovascular, and pupillary function at two visits, separated three months apart. (IRB#: IRB_00135817)
EndoVascular Device for People with Wide-Neck Aneurysms
A wide-neck brain aneurysm is an abnormally enlarged blood vessel usually an artery, due to a defect, disease, or injury. The EndoVasucular device is to help people with the aneurysm. Research is needed to learn the safety and effectiveness of the device. The information we gain may aid future patients. (IRB#: IRB_00131046)
ENG Implant: A Birth Control Study
ENG implant, a birth control method, placed under the skin of a persons arm, has been found to be highly effective, long-lasting, and reversible. However, research is needed to develop plans for counseling women when to begin using ENG as a birth control method. Time Commitment: Time varies Location: In-person at a University of Utah clinic Compensation: Up to $1100 *Participation is confidential (IRB#: IRB_00129999)
Environmental Impact
Research is needed to learn if where people prefer to live helps them understand the environmental impact. Information learned will help us design strategies that can protect against environmental deterioration, specifically in Utah. (IRB#: IRB_00152522)
Eosinophilic Esophagitis Dietary Effects
Eosinophilic Esophagitis is a disease that often causes allergic reactions to types of food. When patients with this disease eat certain foods, they may have trouble swallowing and get food stuck in their esophagus. Over time, scarring and narrowing of the esophagus can occur. Currently, the only way for patients to identify the types of food that trigger the disease is to eliminate foods from the diet. This requires endoscopy with biopsies every 6-8 weeks after each diet change. Research is needed to develop a better way to diagnose and improve the health of people with Eosinophilic Esophagitis disease. (IRB#: IRB_00149437)
EsoCheck a Tool to Find Barretts Esophagus (BE)
Barretts Esophagus (BE) is when a person's tube connecting the throat to the stomach is damaged from stomach acid. BE causes cells to grow which can cause cancer in the esophagus. EsoCheck is a tool that collects cells. The cells are put into EsoGuard to see if a person has BE. Research is needed for us to understand the effects of using EsoCheck and EsoGuard together. The information we learn will help us know if this works as well or is better than what is done now to find if a person has BE. (IRB#: IRB_00131631)
EsoCheck to Identify People with Barretts Esophagus
Barretts Esophagus (BE) is when a person's tube connecting the throat to the stomach is damaged from stomach acid. BE causes cells to grow which can cause cancer in the esophagus. EsoCheck is a tool that collects cells. The cells are put into EsoGuard to see if a person has BE. Research is needed for us to better understand the effects of EsoGuard on identifying people with BE. The information helps us learn how to improve ways to know if people have BE. (IRB#: IRB_00130827)
Evaluating Real-World Use of CDPATH, a Crohns Disease Risk Prediction Tool
The primary objective of the study is to explore the use of a CD risk prediction tool (i.e., CDPATH) to describe the risk profiles of patients with CD in real-world practice. (IRB#: IRB_00151739)
Evaluation of Sensory Tricks in Individuals with Laryngeal Dystonia or Essential Vocal Tremor
Laryngeal dystonia (LD) is a rare neurogenic voice disorder that results in an intermittently strained-strangled or breathy voice quality during speaking. Essential tremor of the voice (ETv) is another neurogenic voice disorder typically perceived as a shaky voice quality but sometimes associated with a similar voice quality to LD, making it challenging for clinicians to distinguish these voice disorders. A correct diagnosis is essential for accurate and effective treatment of these voice disorders. However, clinical voice experts often confuse these disorders and frequently disagree with each other when judging voice quality or observing speech structures. Development of clinical tools that help clinicians make the correct diagnosis of these disorders is a priority. Therefore, we propose studying a characteristic of dystonias, sensory tricks. A sensory trick is a phenomenon diagnostic of dystonias described as a short-term improvement of symptoms due to sensory cues like touching or supporting a body part or being distracted by a sound. This phenomenon is well studied in other kinds of dystonia but has not been systematically evaluated in LD. This pilot study aims to evaluate whether sensory tricks improve voice symptoms in those with LD compared to those with ETv. If successful, outcomes will help identify specific sensory trick(s) that most clearly change LD symptoms and show promise for improving correct diagnosis of those with LD. The sensory tricks studied should be accessible and affordable for use during assessment by clinicians to help distinguish those with LD from ETv. Importantly, findings will inform future studies to improve utilization by clinicians. (IRB#: IRB_00130977)
Evaluation of the HAPPIEST program - a collaborative team summer research program
The overall goal of this project is to evaluate the training program at University of Utah of undergraduate students from underrepresented racial/ethnic backgrounds in air pollution-related health research through a faculty-mentored summer program called Health, Air Pollution and Population Initiative in Education and Science Training (HAPPIEST). Since exposure to air pollution and environmental health issues are magnified in racial/ethnic minority communities in the US, this project addresses an important need in biomedical science training for the next generation, as social disparities and the socio-behavioral sciences are becoming increasingly important to health scholarship as well as US national priorities. (IRB#: IRB_00144170)
Exercise Program for Voice
We are looking to determine the effect of a voice exercise program on improving pitch range. We are looking to recruit both active and less active voice users for participation in this study. (IRB#: IRB_00141650)
Expanded Access Treatment with Open-Label Pegunigalsidase Alfa for Fabry Patients
Expanded Access Treatment with Open-Label Pegunigalsidase Alfa for Fabry Patients. (IRB#: IRB_00140105)
Exploring changes in the vocal tract through MRI
We are conducting an MRI study looking at changes in the vocal tract (the area from your throat through your nose). We are looking for vocally healthy individuals to participate in a voice evaluation and an MRI study. The study will require two separate visits, one for the voice evaluation and the other for the MRI. (IRB#: IRB_00149122)
FIREFLY-1
The description and purpose of the study drug is to research the use of an investigational product labeled NA- IP (DAY 101- formerly TAK-580/MLN2480) to treat Low-Grade Glioma and other advanced solid tumors in pediatric and age-of-majority participants (IRB#: IRB_00138633)
Functional Constipation Study - Clinical Trial using Prucalopride compared to placebo
We are asking you to allow your child to take part in a research study for prucalopride (called the study drug) because they have been diagnosed with functional constipation. Constipation happens when your child has fewer than 3 bowel movements a week. Functional constipation is a condition in which your child withholds stool, usually because they are afraid of the pain associated with passing of hard stools or due to social reasons. It is not due to a medical problem. When your child holds stool much longer than normal, this can cause the stool to become harder and packed (impacted) in the rectum. As a result, your child may have difficulties in passing stool. The study drug was approved in the United States in 2018 to treat adults with constipation. It is now being looked at in children with functional constipation. (IRB#: IRB_00141463)
Genfit PBC
The sponsor of this research, GENFIT, is conducting this study to learn more about the efficacy and safety of elafibranor 80 mg. The main objective is to evaluate the effect of daily oral administration of 80 mg elafibranor on cholestasis (impairment of bile formation and/or bile accumulation) in patients with PBC and inadequate response or intolerance to ursodeoxycholic Acid (UCDA). The effect and the safety and tolerability of elafibranor 80 mg will be compared with placebo over a period of 1 to 2 years. The maintenance of the effect and the safety and tolerability of elafibranor 80 mg will continue to be studied during a period of up to 5 years. (IRB#: IRB_00138192)
GT-031: Study Evaluating the Efficacy and Safety of Belapectin (GR-MD-02) for the Prevention of Esophageal Varices in NASH Cirrhosis
The purpose of this study is to find out about the safety and efficacy of Belapectin (GR-MD-002) for the prevention of esophageal varices in NASH (Non-Alcoholic Steatohepatitis) Cirrhosis. Belapectin is an investigational drug that has not been approved by Health Authorities in any country of the world, including the United States Food and Drug Administration (U.S. FDA). Belapectin (GR-MD-02) is a complex carbohydrate drug that targets galectin-3, a critical protein in the pathogenesis (the origin and development of the disease) of fatty liver disease and fibrosis. The drug binds to galectin and disrupts its function. Preclinical data in animals have shown that Belapectin has robust treatment effects in reversing liver fibrosis and cirrhosis. Belapectin has been studied in clinical trials in patients with NASH cirrhosis and showed some evidence of potentially reducing the blood pressure in vessels entering cirrhotic liver and preventing the development of new esophageal varices (Enlarged veins). The esophagus is a muscular tube connecting the throat (pharynx) with the stomach and carries food and liquids to the stomach. The development of esophageal varices is one of the complications of cirrhosis and can cause unexpected and often severe bleeding in the digestive system. (IRB#: IRB_00133562)
Hanmi Treatment for 12 Months in Subjects with Biopsy Confirmed NASH
The purpose of this research study is to evaluate the effects of HM15211 in people with NASH. This study will also evaluate study drug levels in your body and the time it takes your body to eliminate the drug (pharmacokinetics or PK) and what the study drug does to the body (pharmacodynamics or PD). HM15211 is an experimental drug which is not approved by the U.S. Food and Drug Administration (FDA) for the treatment of NASH. Nonalcoholic steatohepatitis (NASH) is inflammation of the liver due to the buildup of fat in the liver cells in patients who drink little or no alcohol. Long-standing inflammation of the liver can lead to scarring (fibrosis). In some patients, NASH can lead to cirrhosis of liver and complications of liver failure. Most patients with NASH have no signs or symptoms. (IRB#: IRB_00136282)
HBS-101-CL-002 Pitolisant in Patients with Prader-Willi Syndrome
This is a research study for patients with Prader-Willi syndrome and have excessive daytime sleepiness (EDS). Harmony Biosciences, the Sponsor, is conducting a phase 2 study to evaluate the safety and effectiveness of pitolisant compared to placebo (a tablet that looks like pitolisant but contains no study drug). This is a study with two parts. Part 1 Double-Blind Period: This part will last about 17 weeks. Participants will have about 5 study visits to the study clinic and 4 phone calls. During the double-blind period, no one will not know the dose of study medication. Part 2 Open-label Period: This part could last more than one year. During this part of the study, Participants will have a study visit once every 3 months for the first year and then every six months for the second and remaining years. (IRB#: IRB_00137020)
HCI-Total Cancer Care Study
This study is a partnership between participants, health care providers, and researchers. Our aim is to better understand what causes cancer and to find better ways to prevent, detect, and treat cancer more successfully while also supporting your family. This study is an opportunity to contribute samples and information that will be used to accelerate cancer research and improve patient care. Participants like you are vital to our success. The study also offers access to a broader set of clinical trials and new treatments through our partnership with other leading cancer centers nationally. There is no cost to be in this study. No matter what you decide, it won't change the relationship with your health care providers to affect the quality of your care. (IRB#: IRB_00089989)
HEALEY ALS Trial
This study is looking at the safety and effectiveness of four different investigational treatment regimens: Zilucoplan, Verdiperstat, CNM-Au8, and Pridopidine for ALS. Each regimen will have an active investigational product and a matching placebo that will be tested. New regimens will be continuously added as new investigational products become available. (IRB#: IRB_00143448)
Health and Safety Consequences of Poor Sleep Health
Sleep is a key factor affecting your overall health. We want to investigate if altering your nightly sleep duration impacts your bodys metabolism (how you metabolize food). We will also look at your physical activity, food intake, and cognition during the study. (IRB#: IRB_00133959)
Hearing Effects in Children with CMV
Cytomegalovirus (CMV) is a virus that can occur in babies ages 0-4yrs old and may cause hearing loss. Research is needed to learn more about hearing loss and its effect on language development. The information will help us understand the best types of care that improve the health of children with CMV. (IRB#: IRB_00151251)
How COVID-19 has Impacted Secondary School Aged Students with Autism
COVID-19 Study
The purpose of this study is to explore the academic, psychological and social experiences of secondary school aged individuals with an autism spectrum disorder during COVID-19. (IRB#: IRB_00135759)
How do children listen in complicated auditory environments?
Children have more difficulty listening in complex environments like a classroom than adults. Children with hearing loss experience even more difficulty than children without hearing loss. Scientists and doctors do not fully understand the characteristics of the environment and the listener that makes listening difficult. Research is needed to design better methods that improve the health of people with listening challenges in complex environments. (IRB#: IRB_00126429)
How does brain function change during a treatment cycle of Botox injections for the voice disorder adductor laryngeal dystonia?
The purpose of this study is to find the locations in the brain that are affected by Botox injections into the throat muscles in patients who have adductor-type laryngeal dystonia (also known as adductor spasmodic dysphonia). Participation in this study involves brain scans along with assessments of the voice muscles. Brain scans involve laying still in a scanner while resting and speaking. Assessment of voice muscles involves small needles inserted into muscles in the voice box. Both procedures are well-tolerated by most people. Participants with laryngeal dystonia will have 2 brain scans and 2 voice muscle assessments over 1 Botox cycle (approximately 3-4 months). A second purpose of this study is to evaluate a specialized speech therapy program for treating laryngeal dystonia. Therapy will take place over 6 months (2 Botox cycles) and will incorporate in-person or virtual session along with home practice. Some participants may be eligible to participate by completing only 2 sets of muscle assessments or 2 sets of voice recordings. (IRB#: IRB_00143531)
How Meditation Reduces Chronic Low Back Pain and Opioid Use By Changing the Brain
We are comparing two different forms of meditation-based group therapy versus usual care for people taking opioids to alleviate chronic low back pain. In this study, you may be randomly selected to participate in one of two different forms of meditation-based group therapy (8 weekly sessions), or to continue with your usual low back pain care. You will participate in a pain challenge where you have your brain scanned while you practice meditation to reduce discomfort caused by heat delivered by a safe scientific instrument. You will be compensated for your participation. (IRB#: IRB_00133405)
Hybrid Team Problem Solving
In the past, research has shown that in-person team problem solving provides better results. Currently, team problem solving is more frequently occurring online or hybrid. Scientists need to learn if hybrid team problem solving can also produce successful outcomes. (IRB#: IRB_00147884)
Impact of Cesarean delivery on future pregnancy
This study is evaluating the impact of prior cesarean deliveries on future pregnancies. To help promote the care and safety of our pregnant patients, the University of Utah is asking women who are trying to get pregnant within the next year to participate. (IRB#: IRB_00144683)
Improve Caregiving for People Living in Rural Nursing Homes Through Technology Intervention
COVID-19 Study
COVID-19 greatly impacted people in nursing homes. Research is needed to understand how to better care for urban and rural nursing home residents, families, and staff. The information learned will help us design the best way to use telehealth that improves the health of all people involved in nursing home care. (IRB#: IRB_00134186)
Improve MRI methods for People with ALS
Amyotrophic Lateral Sclerosis (ALS) is a disease that causes severe loss of motor nerve cells and skills. Currently, neuroimaging, including a brain scan (MRI), is used during the diagnosis of ALS to look for alternative diagnoses. However, research is needed to improve MRI methods that support the diagnosis of ALS. The information learned will help us better understand how to design MRI methods that diagnose people with ALS. (IRB#: IRB_00100646)
Improving Assessment of Executive Functioning in Hispanic/Latino/a Older Adults
Neuropsychological evaluations are often used to help doctors determine how well an individual can live independently. However, many of the tests neuropsychologists use were developed on non-Hispanic White individuals and are not as accurate in Hispanic/Latino/a individuals. The goal of this study is to determine which measures are best for assessing functioning in Hispanic/Latino/a individuals so that neuropsychologists have a better understanding of how improve the accuracy of their assessments. (IRB#: IRB_00145891)
Improving Communication of Patients with Lynch Syndrome, Families, and Genetics Counselors
Cascade Screening is a method of communication that informs relatives of patients with certain hereditary conditions. Scientists and doctors want to improve communication among people with Lynch Syndrome, their families, and genetic counselors. Research is needed to learn the best methods of communication. (IRB#: IRB_00148880)
Improving Congenital Heart Disease Care for Adolescents and Young Adults
Congenital Heart disease (CHD) is one of the most common birth defects with most major effects diagnosed in infancy. Because there is no cure for CHD it is a lifelong chronic illness. Research is needed to understand the needs of people with CHD as they transition from child to adulthood. This information will improve the care and quality of life for people with CHD. (IRB#: IRB_00149991)
Improving Health of Children with MS
Kesimpta® and Mayzent® are potential medications for children with Multiple Sclerosis (MS). Scientists and doctors need to learn the safety and effectiveness of these medications to improve the health of children with MS. (IRB#: IRB_00145728)
Improving Immunity of Mothers and Babies
Pregnancy, especially late pregnancy, often causes more severe diseases including flu and COVID-19. Vaccination during pregnancy can protect pregnant mothers and their babies. Research is needed to learn more about the effects of vaccines to develop plans that improve the immunity of pregnant women and their babies. Time Commitment: Varies Location: In-person at University of Utah hospital and clinic Compensation: Up to $250 *Participation is confidential Inclusion Criteria: Healthy females Ages 18-50 University of Utah employees Received 2021-2022 Flu or any COVID-19 vaccines (IRB#: IRB_00142244)
Improving Mental Health Therapy Inequities and Disparities
Racism is a fundamental cause of health inequities and disparities that severely impact the health of Americans. Research is needed to better understand mental health therapists anti-racist practices with people who identify their race as white. The information learned will help design more equitable strategies for people receiving mental health therapy. (IRB#: IRB_00149225)
Improving MRI for People with Heart Disease
People with heart disease may need an imagining scan known as an MRI. Research is needed to improve MRI methods used for finding heart problems and better determining what is normal and what is a disease. These include myocardial fibrosis. The thickening of tissue in heart muscles. The information we gain may aid future patients. (IRB#: IRB_00154019)
Improving your blood pressure through culinary medicine
High blood pressure is a silent disease that can have devastating consequences. Keeping your blood pressure under control will reduce your risk of developing heart disease, strokes, and even dementia. This study is designed to help you accurately detect if you have high blood pressure, and then get you the treatment you need to keep it under control. In the intervention arm, you will get to participate in a series of cooking classes and learn how to cook foods which will improve your blood pressure without the use of medications. We will discuss components of the DASH diet and teach key culinary skills to help you feel confident preparing and eating more healthful food. If you choose to participate, you will be asked to attend all physician visits, nurse visits, and shared medical visits. You will also be asked to track your blood pressure at home and report it every few weeks to few months. You will be asked to get labs, and weight periodically as well to track your health. (IRB#: IRB_00145096)
Inflammation as People Age
As a person gets older, immune cells in your blood can create inflammation causing swelling and pain in the body. Research is needed to learn the health and effects of these cells. The information we learn in this study will help us design better ways to aid future patients. (IRB#: IRB_00153158)
IONIS: A Study Drug to Improve Symptoms of FUS-ALS Patients
IONIS is a potential drug to reduce the body's production of the FUS protein that may contribute to ALS. Scientists and doctors need to learn the effectiveness, safety, tolerability, and breakdown of this medication to improve the symptoms of people with ALS. (IRB#: IRB_00144685)
Lanifibranor in adult patients with non-cirrhotic non-alcoholic steatohepatitis (NASH) and fibrosis 2 (F2)/fibrosis 3 (F3) stage of liver fibrosis
This Phase 3 study is conducted to evaluate lanifibranor in adults with NASH and liver fibrosis stage 2 or 3 and consists of 2 sequential parts, Part 1 and Part 2, with the following primary objectives and primary endpoint for the definition of treatment effects. (IRB#: IRB_00145070)
LAU-7b: A Study Drug for People Hospitalized with COVID-19
COVID-19 Study
Peoples health with COVID-19 and other medical issues such as high blood pressure or existing lung disease may get worse over time and might need to go to the Intensive Care Unit. LAU-7b is a study drug for people with COVID-19 that also have other medical issues. Research is needed to know if the drug is safe and effective to improve peoples health. The information we learn may aid future patients. (IRB#: IRB_00152353)
Learning and Memory
Building new memories is known to be a long process. However, studies do show new information can be gained quicker if combined with previous knowledge. Research is needed to learn if young healthy adults build memory faster by attaching present experiences with the past. The information we learn may aid future patients. (IRB#: IRB_00155080)
Learning New Movements Across the Lifespan
The goal of this research is to provide a comprehensive investigation into how novel movements are learned and subsequently stored into long-term memory across the human lifespan. (IRB#: IRB_00136894)
Light Therapy for People with Parkinsons Disease (PD) and Sleep Problems
Parkinsons disease (PD) is a long-term decline in a persons health. Often people with this disease have sleep problems. Research is needed to know if light therapy can help people with PD sleep and improve their quality of life. The information we learn may aid future patients. (IRB#: IRB_00132239)
Liver Transplantation in Patients with Cirrhosis and Severe Acute-on-Chronic Liver Failure (ACLF)
Cirrhosis is a disease that causes scar tissue to form in the liver. ACLF is a chronic liver disease that causes liver failure. Research is needed to better understand how people respond to liver transplantation with the combination of these conditions. The information we learn will help us improve the care of people with Cirrhosis and Severe Acute-on-Chronic liver disease. (IRB#: IRB_00142539)
Long-Term Follow-Up of Patients Who Received Lentiviral-Based CAR-T Cell Therapy
People with specific types of cancer such as leukemia and lymphomas may receive Lentiviral-Based CAR-T Cell Therapy. This is to help improve the symptoms of this disease. Research is needed to learn the long-term safety and effectiveness of the therapy. The information we gain may provide further guidance to patients, doctors, and researchers. (IRB#: IRB_00079262)
LPCN 1148 in Male Subjects with Cirrhosis of the Liver and Sarcopenia.
To evaluate the safety and efficacy of 24 weeks of treatment with LPCN 1148 (Oral Testosterone (T)) in cirrhotic men with sarcopenia who are on the liver transplant waitlist. Efficacy of LPCN 1148 will be determined through a range of clinical outcomes and functional and laboratory tests, including overall survival, undergoing liver transplant, delisting from the waiting list due to deterioration of clinical / health status, new or worsening decompensation events, changes in measures of sarcopenia/frailty/myosteatosis, and changes in MELD, CP, and anemia. (IRB#: IRB_00147656)
Madrigal MGL-3196-11: A Possible Medication for Liver Disease
MGL-3196-11, is a potential medication for patients diagnosed with NASH, a liver disease. Scientists and doctors do not know the effectiveness of the medication. Research is needed to learn if the medication can be used to improve the health of NASH patients. (IRB#: IRB_00146635)
MAINTAIN YOUR WEIGHT STUDY
If you have intentionally lost at least 5% of your highest weight in the last 2 years, you may qualify for a study that provides coaching to support you in maintaining your healthy habits & weight loss. The coaching will be provided to participants at no cost. (IRB#: IRB_00132802)
Massage for Generalized Anxiety Disorder (GAD)
Generalized Anxiety Disorder (GAD) is very upsetting and disabling for people. Massage is known to decrease anxiety. Research is needed to study the effects massage has on symptoms of anxiety and the brain. The information we learn will improve our knowledge of massage to provide more options of care for people with GAD. (IRB#: IRB_00153327)
Measuring Peoples Thermal Comfort in Severe Settings Using Virtual Reality (VR)
The thermal environment of working and learning can impact peoples comfort and energy use of buildings. However, people have limited ability to change their thermal environment in severe conditions (e.g., disasters with limited energy supply). Research is needed to understand peoples thermal comfort and reactions in such severe settings. Therefore, an experiment where a person wears a virtual reality (VR) device to get through possible thermally uncomfortable experience in a safe place will be conducted. The information we learn aims to improve the buildings energy efficiency and occupant indoor comfort, especially during disasters. (IRB#: IRB_00154093)
MEDI3506: A Study Drug for People who had Chronic Obstruction Pulmonary Disease (COPD) with a History of Severe COPD
Chronic Obstruction Pulmonary Disease (COPD) is a type of progressive lung disease with symptoms such as difficulty breathing. MEDI3506 is a study drug to help people with COPD. Research is needed to learn the safety and effectiveness of the drug. The information we gain may aid future patients. (IRB#: IRB_00153167)
Migraine Sensory Biomarkers Study
Migraine progression happens when migraines become significantly more severe or frequent. The goal of this research study is to test if sensitivity to ones environment (i.e. light, touch, sound) can predict migraine progression. By testing sensitivity using different sensory measures (such as touch, light, and sound) we hope to understand risk factors that make migraine progress from an episodic, to a chronic (near-daily), problem. The results of this study will then help future efforts to create preventive interventions in people at-risk for developing chronic migraine. Preventive interventions matter because they help avoid medication overuse headache and ultimately lower risk of progression for those with migraine. There are two main tasks of participating in this study: 1) Completing online questionnaires to evaluate headache history and symptom burden (at screening and over the following 12 months) and 2) completing sensory testing (over two visits). There is compensation associated with participation in this study. (IRB#: IRB_00135109)
Migraines and Headaches
Migraines and headaches are one of the most often pain people experience. Research is needed to better understand migraines and headaches. Including the pain, they may cause and quality of life. The information we gain may aid future patients. (IRB#: IRB_00156345)
Mild Traumatic Brain Injury and Reactive Balance
A Mild Traumatic Brain Injury (mTBI) may result in balance difficulties. Research is needed to learn more about how probing the brain and spinal pathways improve a persons reactive balance after an mTBI. (IRB#: IRB_00147689)
Mirum VISTAS
The purpose of this clinical research study is to learn more about the use of the study medicine, volixibat, for the treatment of pruritus (itching) associated with PSC. Volixibat is an experimental treatment, meaning that it has not yet been approved by the US Food and Drug Administration or any worldwide regulatory body. Volixibat is a medicine that lowers circulating bile acid levels that are believed to lead to the itching in patients with PSC. There are no other medicines approved to treat itching in patients with PSC. This is the first time volixibat will be used in patients with PSC. (IRB#: IRB_00137626)
MK-1654 Vaccine Trial to address RSV (Respiratory Syncytial Virus) in Infants
This is a clinical trial that involves research. This trial is testing an experimental vaccine called MK-1654 in infants. The purpose of this trial is to see if the vaccine known as MK-1654 is being studied can prevent illnesses caused by the respiratory syncytial virus (RSV). RSV infections can affect airways, including the mouth, nose, throat, and lungs. Most cases are mild, but RSV can be serious in infants. Currently, there are no approved vaccines for the prevention of RSV in infants. This trial will compare MK-1654 to placebo. A placebo looks like a trial drug, but it has no active ingredients. Study participants are given placebos so that the effects of a drug can be compared against no drug. Use of placebos also prevents the participant and the doctor from knowing whether or not the subject is getting the drug and prevents bias. (IRB#: IRB_00138790)
MK-1654: A Study Drug for Infants and Children at Increased Risk for Severe Respiratory Syncytial Virus (RSV) Disease
Severe Respiratory Syncytial Virus (RSV) is a common virus that can infect the lungs and air passages, such as the mouth, nose, and throat. Most children who get RSV have a mild cold. However, some children who get RSV may become sicker, such as children born before their expected due date or with certain heart and lung problems. MK-1654 is a study drug for in infants and children with RSV. Research is needed to learn the safety and effectiveness of MK-1654 compared with palivizumab, an already approved drug, The information we gain may aid future patients. (IRB#: IRB_00145502)
Modify OLE
The purpose of the study is to evaluate if the long-term intake of the new drug, called lucerastat, is safe and well-tolerated in adults with Fabry disease.You have been asked to take part because you have Fabry disease and have completed the MODIFY study. Fabry disease is a rare, inherited disease caused by a genetic fault (mutation) which leads to a harmful accumulation of fatty substances in the body. This can cause symptoms of pain such as a burning feeling, shocks or shooting pain, tingling, pins, and needles, stabbing or numbness in hands and feet. It can also cause stomach symptoms like diarrhea and stomach pain. Fabry disease can also cause damage to vital organs like the heart, kidney, and brain. (IRB#: IRB_00137274)
Motor Learning and Brain Development
Motor learning is how a person functions using the brain. Young adult brain development is known as the best motor learning and memory behaviors. Some studies show a childs brain may be better at these. Research is needed to find if a childs brain is greater at motor learning and memory-related behaviors. The information we gain may aid future patients. (IRB#: IRB_00155118)
Multiple Sclerosis (MS), Autoimmune Diseases, and Infection
The cause of Multiple sclerosis (MS) and autoimmune diseases is unknown. The effects of these can severely hurt a persons brain, spinal cord, and body. We want to understand how infections may relate to the diseases. The information we learn can aid future patients. (IRB#: IRB_00047316)
Muscle health recovery after inactivity
The main goal of this study is to better understand the recovery of muscle health following a period of inactivity. (IRB#: IRB_00130232)
Muscle loss during a short period of inactivity and older adults
We are looking for adults over the age of 60 who are in overall good health, and exercise regularly. The main goal of this study is to determine the effects of the medication, Metformin, during a short-term period of physical inactivity, on your muscle health. (IRB#: IRB_00093579)
NAP-HC Study
This brain imaging study will enroll healthy participants in order to compare brain function measures to a separate group of individuals with depression. (IRB#: IRB_00138372)
NERVE TRANSFERS TO IMPROVE UPPER EXTREMITY FUNCTION AND QUALITY OF LIFE IN TETRAPLEGIC PATIENTS
The purpose of this study is to gather information about the treatment of Spinal Cord Injury (SCI) through the use of a surgical procedure known as a nerve transfer. SCI is a devastating condition which is thought to affect nearly 40 cases per million persons annually in the US. More than 50% SCI occur in the cervical spine (i.e., tetraplegia), resulting in some loss of arm and/or hand function. Nerve transfers are used to improve upper extremity and hand function in patients who have suffered from SCI. This is a treatment option that is available to all (appropriate) patients, and participation in this study is not necessary to receive this treatment. Participation in this study is voluntary, and is available only to those who meet certain eligibility criteria. These criteria will be reviewed on a case by case basis by the University of Utah Department of Neurosurgery's study team as potential participants express their interest in the study. Various appointments and/or diagnostic procedures may be scheduled in order to ensure the eligibility of potential patients. There is no financial cost to patients (aside from the standard costs of care) who participate in this study, and there are no direct financial benefits provided for doing so. Participants will be followed after the procedure both by the surgeon and the physical therapy team. This study does provide funding for the physical therapy services utilized in the long-term follow up phase, but this funding is limited. So participants are encouraged to schedule these visits appropriately. The information provided on this page is not exhaustive, so those who are interested in this study are encouraged to contact our study team to discuss any questions they might have. You can do this by contacting the study coordinator, Kirby Taylor, via telephone or email. (IRB#: IRB_00126462)
NFX-179: A Study Drug for Cutaneous Neurofibromas
NFX-179 Gel is a study drug to reduce the growth of benign tumors that grow from small nerves under the skin called cutaneous neurofibromas (cNF). Scientists and doctors do not know the safety and effectiveness of the treatment. Research is needed to learn if it may be approved and used to improve the health of people suffering from cNF. (IRB#: IRB_00147755)
Nintedanib: A Study Drug for COVID-19 Interstitial Lung Disease (ILD)
COVID-19 Study
Nintedanib is a study drug to slow the rate of lung scarring from interstitial lung disease (ILD), a lung injury caused by COVID-19. Scientists and doctors do not know the effectiveness of the treatment. Research is needed to learn if the drug may be approved and used to improve the health of people suffering from ILD. (IRB#: IRB_00148442)
Non-Contact Depth Sensing Respiratory Monitoring in Sleep Study Patients
The purpose of the study is to test an investigational technology using a special camera (investigational software) that can sense the chest rising and falling during breathing and does not attach to the body. The data the camera records will help determine if the investigational technology is reasonable for use in the hospital or other applicable setting. The camera does not have any physical contact with the patient. The investigational technology will be used during your standard of care sleep study. (IRB#: IRB_00146568)
Novo Nordisk: NASH and semaglutide
We are doing this study to see if the medicine called semaglutide can help patients with NASH get better and reduce their risk of future liver complications. NASH is a disease where fat, inflammation and scar tissue build up in the liver. Semaglutide may improve these liver damages. By improving liver damage it might be possible to prevent future liver complications. Semaglutide is already used by doctors to treat patients with type 2 diabetes in many countries. It is also used in research studies of patients with obesity and of patients with different stages of NASH. (IRB#: IRB_00139687)
Obinutuzumab: A Study Drug for Lupus Nephritis
Obinutuzumab is a study drug to reduce the B cells of lupus nephritis. The drug is currently approved for certain blood type cancers such as leukemia and lymphoma. However, scientists and doctors do not know the effectiveness of the treatment for patients with lupus nephritis. Research is needed to learn if the drug may be approved and used to improve the health of people suffering from lupus nephritis. (IRB#: IRB_00145715)
Parent and Teenage Views of Smartphone Spare Time Use on Identity and Self-Image
Parents and teenagers have views about the impact smartphones have on teenagers. Research is needed to know how using smartphones during spare time impacts teenagers identity and self-image. The information we learn may aid future patients. (IRB#: IRB_00152245)
PD0053: A Study Drug for People with Parkinson's Disease
Parkinsons disease (PD) causes nerve damage in the brain making it difficult for people to move. This study will help to determine if the study drug can slow the progression (worsening) of PD. Due to the way the study drug works in the brain, it is not expected to provide immediate relief to PD symptoms, but it may be able to delay their start or reduce their intensity in the long term by protecting neurons. (IRB#: IRB_00154901)
Percutaneous Peripheral Nerve Stimulation (PNS): A Therapy for People with Chronic Low Back Pain (LBP)
Chronic low back pain (LBP) is a major health concern for many people. Many current therapies to help LBP do not work well. Percutaneous peripheral nerve stimulation (PNS) has been shown to relieve LBP and improve quality of life. Research is needed to learn the safety and effectiveness of percutaneous PNS. The information we learn may aid future patients. (IRB#: IRB_00132843)
Personalized Survival Data for Decision Making in the Cancer Journey
We need your help to explore patient and caregiver needs when making decisions about new cancer treatment with an oncologist. (IRB#: IRB_00131189)
PH94B: A Possible Medication for Social Anxiety Disorder
PH94B is a potential medication for patients with Social Anxiety Disorder. Scientists and doctors do not know the safety and effectiveness of the drug. Research is needed to learn if the medication may be used to improve the health of patients with Social Anxiety Disorder. (IRB#: IRB_00145861)
Physical Therapist 6 Minute Walk Test for Adults
Physical therapists that provide rehabilitation services to adults often use a test called the 6 Minute Walk Test (6MWT) to track a patients progress and set goals for their walking. Currently, a 6 minute 100 feet walk test is used. However, because 100 feet takes up a lot of space, using this test is not always easy in a rehabilitation clinic or a patients home. Research is needed to learn how far adults typically walk on a 39 feet pathway in 6 minutes. This information will improve the ability for physical therapists to track progress and design treatment plans for people with a variety of health conditions. (IRB#: IRB_00150989)
PLN-74809: A Study Drug for People with Idiopathic Pulmonary Fibrosis (IPF)
Idiopathic Pulmonary Fibrosis (IPF) is a respiratory illness in a persons lungs. PLN-74809 is a study drug for people with IPF. Research is needed to know if the drug is safe and effective. We also want to find out if any changes occur in a persons IPF. The information we learn may aid future patients. (IRB#: IRB_00138725)
PNOC-013 Study of Single Agent REGN2810 in Pediatric Patients with Relapsed or Refractory Solid or Central Nervous System (CNS) Tumors and a Safety and Efficacy Trial of REGN2810 in Combination with Radiotherapy in Pediatric Patients
This study is being done to test if cemiplimab (study drug-REGN2810) can reduce the size of a tumor by helping the immune system destroy the tumor. The study is also being done to test the safety of cemiplimab in pediatric patients. (IRB#: IRB_00109601)
Prenatal Latina Discrimination
Studies show that pregnant Latina women are 10-20% more likely to have their babies before the due date. A reason for this may be the greater stress caused by racial discrimination. Research is needed to help scientists and doctors learn how to create better health care for pregnant Latinas. Time Commitment: Approx. 3 weeks Location: Home and smartphone Compensation: Up to $60 *Participation is confidential (IRB#: IRB_00141088)
Prevention for People with Type 2 Diabetes
A persons lifestyle shows to help prevent diabetes. A persons health may be influenced by their partner. Research is needed to learn how useful and successful a diabetes prevention program is when educating a patient with type 2 diabetes and their partner. The information we gain may aid future patients. (IRB#: IRB_00143079)
PRM-15: A Study Drug for People with Idiopathic Pulmonary Fibrosis (IPF)
IPF is a rare, specific form of chronic, fibrosing, interstitial pneumonia limited to the lung and leads to an irreversible loss of lung function. We are studying PRM-15 to see if it is safe and effective at preventing this severe condition. Research is needed to determine if the study drug may be approved for use to heal and reduce fibrosis in adults with IPF (IRB#: IRB_00139581)
PRM-151: A Study Drug for People with Idiopathic Pulmonary Fibrosis (IPF)
PRM-151 is a study drug to slow down scarring (fibrosis) of the lungs. Scientists and doctors do not know the safety and effectiveness of the drug. Research is needed to learn if it may be approved and used to improve the health of people suffering from IPF. (IRB#: IRB_00148544)
PTC923-MD-003: A Study Drug for Patients with Phenylketonuria (PKU)
PKU (Phenylketonuria) is caused by a defective gene. When a person with PKU eats foods that contain protein, or eats aspartame, an artificial sweetener, a dangerous buildup of phenylalanine can occur. PTC923 is a study medication to reduce blood Phenylalanine (Phe) levels. This study will assess the safety and how effective this medication is for those of any age with a PKU diagnosis. (IRB#: IRB_00150374)
Pulsed, Inhaled Nitric Oxide (iNO): A Study for People with Fibrotic Interstitial Lung Disease (fILD) on Long Term Oxygen
Fibrotic Interstitial Lung Disease (fILD) is a serious disease that makes it hard to breathe. People with this disease may be on long-term oxygen to breathe. Research is needed to learn if inhaling nitric oxide (iNO) through the INOpulse® system can help people with fILD at risk of worsening lung disease. We want to know if doing this can improve a persons activities, such as walking, climbing stairs, and cleaning. The information we gain may aid future patients. (IRB#: IRB_00138396)
Radiofrequency Ablation for People with Refractory Phantom and Residual Limb Pain
Residual limb (RLP) and phantom limb pain (PLP) may occur in patients post-amputation. Cooled Radiofrequency Ablation (C-RFA) is a treatment for these symptoms. Research is needed to learn the effect C-RFA has on improving a patients pain, physical function, and quality of life. The information we learn will aid future patients. (IRB#: IRB_00106250)
Ravulizumab: A Study Drug for Infants, Children, and Young Adults Ages 1 month to 18 years old with Thrombotic Microangiopathy (TMA) after Hematopoietic Stem Cell Transplant (HSCT
Thrombotic Microangiopathy (TMA) is blood clots that form in the body from damaged cells. Hematopoietic stem cell transplant (HSCT) is when other cells are used from a persons body to create normal blood cells. Ravulizumab is a study drug to help infants, children, and young adults ages 1 month to 18 years old with this disease after having HSCT. Research is needed to learn if the drug is safe and effective. The information we gain may aid patients. (IRB#: IRB_00135225)
Realize Trial for Drug resistant focal onset seizures
In this study, doctors want to find out if an investigational drug called CVL-865 is effective in decreasing the number of focal onset seizures, also known as partial seizures, without causing too many side effects. (IRB#: IRB_00130130)
RECOVER Study: COVID-19 infection and illness rates in Essential Workers
COVID-19 Study
This study is a multi-site prospective study focusing on SARS-CoV-2, or COVID-19, infections among essential workers (EW). EW are at high-risk because they are on the front lines of the COVID-19 pandemic. Further research is needed in order to help identify occupational groups that may be more vulnerable within EW. This study is voluntary, meaning you decide whether or not you want to participate. The purpose of this study is to understand the risks of infection and the immune response against SARS-CoV-2, the virus that causes COVID-19. (IRB#: )
RECOVER Study: COVID-19 infection and illness rates in Essential Workers
COVID-19 Study
This study is a multi-site prospective study focusing on SARS-CoV-2, or COVID-19, infections among essential workers (EW). EW are at high-risk because they are on the front lines of the COVID-19 pandemic. Further research is needed in order to help identify occupational groups that may be more vulnerable within EW. This study is voluntary, meaning you decide whether or not you want to participate. The purpose of this study is to understand the risks of infection and the immune response against SARS-CoV-2, the virus that causes COVID-19. (IRB#: IRB_00134376)
Registry for Adenomas of the PItuitary and related Disorders (RAPID)
This study is a surgical registry for patients who undergo surgical resection of pituitary adenomas. The registry allows surgeons and researchers to obtain more accurate data from patients because it is prospective, meaning it data is entered as the patient is treated. One problem with all prior studies is that patient charts are reviewed after treatment which can result in inaccurate data and bias. Clinical data such as visual function, endocrinology function, surgery time, and length of stay will be acquired in addition to other variables. Samples of removed tumor will be stored in the Huntsman Tumor Biobank. Patients will also be provided quality-of-life surveys, brief evaluations done at the time of clinic follow-up or by email, that allows surgeons to better understand how surgical treatment is helping their patients' life at home, ability to reenter the workplace, etc.The purpose of this study is to evaluate best practices, improve the accuracy of epidemiology information, and improve patient outcomes. This registry is part of a multicenter study where the top centers of excellence in the treatment of pituitary adenoma are collaborating to study their data together. Future plans for the registry are to expand to other types of skull base tumors to better understand patient treatment and improve outcomes. (IRB#: IRB_00144784)
Repeating Measures of Daily Functioning in Those at Risk for Alzheimer's Disease
The goal of this study is to see how tests of daily functioning and thinking change when they are repeated across one week. This study may also help doctors learn more about how these changes across one week predict risk for Alzheimers disease. (IRB#: IRB_00144575)
Rifaximin Soluble Solid Dispersion (SSD) Tablets for the Delay of Encephalopathy Decompensation in Cirrhosis (RED-C)
Encephalopathy Decompensation in Cirrhosis (RED-C) is the breakdown of the liver in a person with liver disease. Rifaximin soluble solid dispersion (SSD) tablet is a study drug that may delay symptoms. Research is needed to learn the safety and effectiveness of this drug. The information we learn will aid future patients. (IRB#: IRB_00154389)
Rifaximin Soluble Solid Dispersion (SSD) Tablets for the delay of Encephalopathy Decompensation in Cirrhosis (RED-C)
The primary objective of this study is to assess the efficacy of rifaximin SSD-40IR versus placebo to delay the occurrence of HE-related hospitalization (IRB#: IRB_00151832)
Sacral Neuromodulation Treatment to Improve Bladder Function and Quality of Life
Sacral neuromodulation is a treatment that may be given to improve bladder function and quality of life after a severe spinal cord injury. Research is needed to learn the safety and effectiveness of the intervention so it may be approved and used to improve the health of people suffering from spinal cord injury. (IRB#: IRB_00096153)
Selexipag: A Drug to Study for Children and Adolescences with Pulmonary Arterial Hypertension (PAH)
Pulmonary Arterial Hypertension (PAH) is a type of high blood pressure that affects the arteries in the lungs and heart. Selexipag is an approved drug for adults with PAH. Research is needed to know if the drug is safe and effective for children and adolescents with PAH. The information we learn may aid future patients. (IRB#: IRB_00135477)
Setanaxib with a 52-week Extension Phase in Patients with Primary Biliary Cholangitis (PBC) and Elevated Liver Stiffness
To evaluate the effect of setanaxib on biochemical response at Week 52 in patients with PBC and with elevated liver stiffness and intolerance or inadequate response to UDCA (IRB#: IRB_00151228)
Skin Cancer Prevention Education for Pregnant Mothers and Their New Babies
Skin cancer is the most commonly diagnosed cancer in the United States. Parents are important in their childrens sun safety. Research is needed to find out how possible and effective it is to provide sun protection education to pregnant mothers. While studying the effects of the mothers sun protection actions. The information we learn will aid future patients. (IRB#: IRB_00150970)
SL-1002 Injection Treatment for People with Knee Pain and Osteoarthritis (OA)
Osteoarthritis (OA) is a disease that causes joint pain. This can occur in the knee. The Corticosteroid dexamethasone injection is used now to help people with OA knee pain. The human amniotic fluid epidural injection is a new way to treat this pain. Research is needed to learn the safety and effectiveness of the new injection and see which injection is better at improving symptoms. The information we learn will aid future patients. (IRB#: IRB_00154817)
Sofosbuvir (SOF) and Velpatasvir (VEL): Study Drugs for Pregnant Women with Hepatitis C
Hepatitis C is an infection in the liver. Sofosbuvir (SOF) and Velpatasvir (VEL) are approved drugs for people with Hepatitis C. These drugs are not approved for pregnant women with Hepatitis C. Research is needed to know the safety and effectiveness of these SOF and VEL for use in pregnant women. The information we learn may aid future patients. (IRB#: IRB_00152415)
Storing Information for People with Mood Disorders
Mood disorders like major depressive disorder and bipolar disorder can be long-lasting, reoccurring illnesses. Current ways to help many people often have major barriers. We wish to create a place for research to be stored for people with mood disorders. This will help us design and recruit people to participate in current and future studies of mood disorders. (IRB#: IRB_00154013)
Study in Parkinson Disease of Exercise
This study seeks to determine if aerobic exercise influences the progression of Parkinson Disease severity. Based on previous research, we believe that aerobic exercise may protect the brain cells from being damaged and this study hopes to provide more specific evidence regarding this potential benefit. (IRB#: IRB_00136463)
Study of Eye Diseases That Lead to Visual Impairment
COVID-19 Study
There are certain eye diseases inherited and passed on from parents. Age-related macular degeneration and glaucoma are two of these diseases. Both can create vision loss or blindness. We are doing this research to find out more about the causes of these diseases and others. This will help us to know how best to test, treat, and maybe cure them. The information we learn in this study will aid future patients. (IRB#: IRB_00010201)
Study of the Efficacy and Safety of Oral AMT-101 in Subjects with Moderate to Severe Ulcerative Colitis
Study of the Efficacy and Safety of Oral AMT-101 in Subjects with Moderate to Severe Ulcerative Colitis (IRB#: IRB_00134739)
Study Ozanimod an Approved Drug for People with Crohns Disease
Crohns disease (CD) can cause severe pain and swelling in a persons stomach. Ozanimod is an approved drug that can help people with this disease. We are doing this research to know more about how well ozanimod works. The information we learn in this study will aid future patients. (IRB#: IRB_00115515)
Study the Comaneci Device for People with Brain Aneurysm
A brain aneurysm is a dilation off of a blood vessel, usually an artery, due to a defect, disease, or injury. Rupture of the aneurysm with resultant bleeding around the brain is the main risk that an aneurysm poses. The Comaneci device is an approved way to help people with this health issue. Research is needed to learn more about the safety and effectiveness of the device. The information we gain may aid future patients. (IRB#: IRB_00136960)
Studying how valid and accurate a smart application is compared to the gold standard
Thus, the purpose of this study is to test the validity and reliability of the OneStep software app (Celloscope Ltd., Tel Aviv, Israel) compared to the motion capture system (Vicon, Oxford Metrics Ltd., Oxford, UK) in relatively young (<45 years) and older (>45 years) adults. After evaluating the the OneStep app to the lab, we might be able to use with patients to help them in their recovery after surgical or rehab. (IRB#: IRB_00138995)
Suicidal Thoughts or Behavior During and After Pregnancy
Pregnancy can be a stressful time in a womans life. This may cause women to have thoughts or actions about self-harm or suicide while they are pregnant. Research is needed to learn more about the effects of motherhood on mental health. The information we learn will help us provide better support for all women during and after pregnancy. (IRB#: IRB_00126952)
Suicide prevention study
We are studying how therapy can help 1850-year-olds.Your input will help us understand suicide therapy interventions. The eligibility survey is quick with a confidential online screening meeting scheduled at your convenience. If you complete all the study procedures, you receive a total of $82 in electronic gift cards. (IRB#: IRB_00135355)
Synpheny
The study drug being evaluated in the SynPheny-1 Study is a modified probiotic. It is designed to help breakdown of Phe in the body, which may help with managing and preventing PKU symptoms. It is an oral powder designed to be mixed with water and taken after meals. (IRB#: IRB_00139019)
Test to Determine Children with Idiopathic Membranous Nephropathy (IMN)
Idiopathic Membranous Nephropathy (IMN) is a kidney disease. Research is needed to find out if blood tests predict when a child may have IMN. The information we learn will aid future patients. (IRB#: IRB_00152942)
Testing differences in responses to COVID-19 vaccines
COVID-19 Study
This study will test for differences in antibody responses and side effects following COVID-19 vaccination between healthy people and those with medical conditions that affect the immune system. Participants will answer survey questions and provide additional medical information as well as blood samples with their first vaccine dose and at 6 additional times in the first 12 months after vaccination. (IRB#: IRB_00139840)
TETON: A study of an experimental drug called inhaled treprostinil in people with IPF
The purpose of this research study is to see how well inhaled treprostinil (brand name Tyvaso®) works in participants with IPF and to gather information on how safe it is. Inhaled treprostinil works by keeping the pulmonary arteries open to allow more blood with oxygen into your lungs and may reduce lung scarring. In the study, you will receive either inhaled treprostinil or placebo. Placebo is made to look exactly like inhaled treprostinil but does not contain any medicine. You will not know if you are receiving treprostinil or placebo. Treprostinil and placebo are given by breathing in the medicine into your lungs using a machine called a nebulizer (inhaling device). The nebulizer changes the medicine into a mist for you to breathe into your lungs. Your participation in this study will last approximately 58 weeks. If you choose to participate, you will be required to come to about 8 in clinic visits, have blood drawn, perform lung function tests, and take the study drug daily. (IRB#: IRB_00143600)
The Attention of Expert Boxers
Making instant decisions is important in a variety of settings, including sports such as boxing. When time is limited, decision-making success is strongly determined by things that influence immediate attention. Research is needed to learn whether expert boxers show better attention skills compared to untrained persons. The information we learn may aid future patients. (IRB#: IRB_00155440)
The Effect of Planning to Balance During Walking, Stepping, or Jumping Interruptions
Research is needed to find how people balance during expected or unexpected walking, stepping, or jumping. interruptions. The information we learn will help us better understand how to support people with balancing challenges. (IRB#: IRB_00145032)
The HERO (Help Reduce organic Acids) Study
The HERO study is evaluating an experimental drug for methylmalonic acidemia (MMA) and propionic acidemia (PA). The study drug, called HST5040, is an oral therapy designed to correct metabolic abnormalities associated with MMA and PA. HERO will be conducted at select leading childrens hospitals in the United States. The HERO Study is recruiting participants age 2 and older with MMA or PA. The study is not enrolling patients who have had transplants at this time. (IRB#: IRB_00142396)
The Intracept Procedure for People with Low Back Pain
The Intracept procedure is given by a patients specific doctor for low back pain. The procedure is approved by the (Food and Drug Administration) FDA. Research is needed to learn more about how well and safe it is at helping a persons lower back pain. The information we learn will aid future patients. (IRB#: IRB_00130205)
Thrombectomy Treatment for Patients with Acute Ischemic Stroke
An acute ischemic stroke (AIS) is a sudden loss of blood flow to an area of the brain. Currently, Thrombectomy is a successful treatment used for removing blood clots from the brain after an AIS. Research is needed to learn more about the safety and effectiveness of the treatment to improve the health of patients with AIS. (IRB#: IRB_00135249)
Tisagenlecleucel (CTLO19): A Drug for People with Acute Lymphoblastic Leukemia (ALL) or Diffuse Large B-Cell Lymphoma (DLBCL)
Lymphoblastic leukemia (ALL) or diffuse large b-cell lymphoma (DLBCL) is a cancer of the blood and bone marrow. CTLO19 is a drug to help people with this disease. Some patients do not meet the guidelines to get the drug. Research is needed for these patients to receive CTLO19. The information we learn may aid future patients. (IRB#: IRB_00115875)
Tocilizumab or TCQ: A Study Drug for Pediatric Patients with COVID-19
COVID-19 Study
Tocilizumab or TCQ is a study drug to help pediatric patients hospitalized with COVID-19. Research is needed to learn if it is safe and effective for these patients. The information we gain may aid futures patients. (IRB#: IRB_00150759)
TRADIPITANT: A Study Drug to Help People with Gastroparesis
Tradipitant is a study drug to help people with symptoms of gastroparesis, a stomach disease. Research is needed for us to know the effects of the study drug. The information we learn will help us understand if it can improve the health of people with gastroparesis. (IRB#: IRB_00129133)
Treating Obstructive Sleep Apnea with the Aura6000® System
The aura6000® system is a device that helps open the airway while a person sleeps to prevent obstructive sleep apnea (OSA). Research is needed to see if it is safe and effective to reduce OSA. This information will help determine if this device may be used to improve the care and quality of life for people with OSA. (IRB#: IRB_00150772)
TREO PAS
You may decide to volunteer. You are free to decide to join this research or not to join this research. You may be asked to take part in this research if your doctor feels that you may be a good candidate to be treated with the TREO Abdominal Stent-Graft. The Food and Drug Administration (FDA) has approved this TREO medical device to treat abdominal aortic aneurysms (AAA) for endovascular (EVAR) (not open) surgeries. The purpose of this research is to help determine the long-term performance of the TREO Abdominal Stent-Graft as a treatment for patients with AAA. After your EVAR repair with the TREO Abdominal Stent-Graft, you will return to your doctor for 1-month and 12-month follow-up visits. Following the 12-month follow-up, you will return once a year for 5 years. Patients who enroll will do 8 visits in total over 5 years. There is no randomization or blinding the treatment. All eligible patients who can have EVAR surgery and TREO Abdominal Stent-Graft to treat AAA are welcome to join. (IRB#: IRB_00138928)
Ultraviolet Ray Prevention for Children
Melanoma is the 6th most common type of skin cancer in the United States. The just-in-time intervention (JITAI) application (app) is a tool used on a cell phone. The tool can help children and adults know how much time in ultraviolet rays (UVL) from the sun. Research is needed to learn what children and adults think about using the JITAI app. We hope to reduce the time children spend in UVR, so sunburns occur less. (IRB#: IRB_00121617)
University of Utah Long Covid Registry
COVID-19 Study
Researchers at the University of Utah have established a registry to follow individuals who are experiencing prolonged symptoms after COVID-19 infection. We are interested in following people with "Long Covid" using in depth health surveys and optional blood draws to better understand this condition with the goal of ultimately developing clinical management strategies. (IRB#: IRB_00140978)
Using Mindfulness Techniques to Treat Chronic Pain and Reduce Opioid Use
In this study, we will teach participants mindfulness techniques to help them cope with chronic lower back pain. You must be at least 18 years of age with a diagnosis of lower back pain and taking a prescription opioid medication to participate. Those who choose to enroll will participate in 4 weeks of group therapy (30 minutes per week) group sessions led by a masters-level therapist and prescribed daily at-home mindfulness practice. Participants will be evaluated using interviews and surveys before, after, and during the group therapy intervention. (IRB#: IRB_00135443)
Using neuroimaging to predict chronic pain and medication use
Chronic pain impacts one in every five people in the United States. In this study, we are using brain imaging technologies to better understand chronic pain and to help inform future efforts to develop more effective, personalized treatment strategies for people affected by chronic pain. Specifically, we are interested in seeing whether measures of brain activity can predict future pain and pain medication use. For this study, we are recruiting individuals who are willing to be scanned using functional MRI and to fill out monthly surveys over 6 months. (IRB#: IRB_00128585)
Vaccinations for People with Influenza (flu)
The Influenza (flu) vaccination is the most effective method of preventing the flu and other health-related issues. There are many types of flu vaccines. One type is a newer flu vaccine called a recombinant (new gene combination) and another is a standard egg-based flu vaccine. We want to know which Food and Drug Administration (FDA) approved vaccine works best. The information we gain may aid future patients. (IRB#: IRB_00157020)
Venetoclax: A Study Drug for Children and Young Adults with Resistant or Reoccurring Types of Leukemia or other Specific Cancer
Children and young adults may have resistant and reoccurring types of Leukemia or other specific cancer. Venetoclax is a study drug for these types of cancer. Research is needed to learn how well Venetoclax works with and without chemotherapy. The information we learn may aid future patients. (IRB#: IRB_00103319)
VenoValve: An Investigational Device for Patients with CVI
Chronic Venous Insufficiency (CVI) is a debilitating condition that involves leg pain, leg swelling, enlarged veins, skin discoloration, and open sores on the lower legs. VenoValve® is an investigational device that may resolve severe CVI symptoms. Scientists and doctors do not know the safety and effectiveness of this device. Research is needed to learn if it may be approved and used to improve the health of CVI patients. To learn more about the investigational VenoValve treatment being studied, please visit www.VenoValve.com. (IRB#: IRB_00146913)
Volixibat: A Possible Rare Liver Disease Medication
PBC is a chronic rare liver disease. Volixibat is a potential medication for symptoms of this disease. Scientists and doctors do not know the safety and effectiveness of this drug. Research is needed to learn if it may be approved by the United States Food and Drug Administration (FDA) and then used to improve the health of PBC patients. (IRB#: IRB_00148152)
ZYN002: A Study for Children and Adolescents with Fragile X Syndrome (FXS)
Fragile X Syndrome (FXS) is when a gene in a persons body stops making protein. This protein is needed for a persons brain development. ZYN002 is a gel put on the skin to help children and adolescents with FXS. Research is needed to learn more about the efficacy and safety of ZYN002. The information we gain may aid future patients. (IRB#: IRB_00146490)