Search Criteria: Brain Health Studies;
A First-In-Human (FIH) Study of Inhibitory Interneurons (NRTX-1001) in Drug-Resistant Unilateral Mesial Temporal Lobe Epilepsy (MTLE)
(IRB#: IRB_00157503)
NRTX-1001 is a study drug to help people with drug-resistant mesial temporal lobe epilepsy MTLE. We need to learn the safety and effectiveness of NRTX-1001 for it to be approved by the Federal Drug Administration (FDA) and used to help people with MTLE. The information we gain may aid future patients.
- All genders
- Over 18 years old
- Volunteers with special conditions
- In Person
- Paid
A Study for People with Epilepsy
(IRB#: IRB_00146602)
Idiopathic generalizable epilepsy (IGE) is a common form of epilepsy. IGE impacts several million people. This disease can increase risks for other health conditions. Research is needed to better understand what people with newly or established IGE diagnoses need to help them improve their quality of life. The information we gain may aid future patients.
- All genders
- Over 18 years old
- Volunteers with special conditions
- In Person
- Paid
A Study of Children and Adults with Tuberous Sclerosis Complex-related Epilepsy
(IRB#: IRB_00150885)
Ganaxolone is a study drug to help children and adults with Tuberous Sclerosis Complex-related (TSC) Epilepsy. Research is needed to learn how safe and effective the study drug is at reducing the number of seizures a child or adult has when added to the current epilepsy treatment and drug(s).
- All genders
- All Ages
- Volunteers with special conditions
- In Person
- Paid
A Study to Test Reflexes with Electrical Stimulation
(IRB#: IRB_00166846)
The purpose of this study is to compare reflexes (a muscle reaction in the body) electrically stimulated on the leg or arm and lower back. Electrical stimulation is when a safe stick-on patch is placed above the skin to help reduce pain. We want to see how reflexes change with age, in different muscles and electrically stimulated places. We also want to learn how comfortable the electrical stimulation is on the back by comparing two other different common ways used to treat pain. The study requires a 3.5-hour visit to a University of Utah clinic. During the visit, reflexes will be tested on the leg or arm and back in electrically stimulated places. Participants will be paid $45 for participation. The information we learn will guide us to develop an electrical stimulation method to treat pain and restore movement in the arms and legs.
- All genders
- Over 18 years old
- Healthy Volunteers
- In Person
- Paid
Adaptive Cycling for People with Paralysis
(IRB#: IRB_00166092)
This study is to establish a live-cast adaptive spinning program for individuals 18 years and older who have paralysis living outside of Salt Lake County, Utah County, Weber Count, and Davis County. Participate in adaptive spinning twice a week for 60 minutes over 8 weeks from your home. We will loan a cycle for you to participate.
- All genders
- Over 18 years old
- Healthy Volunteers
- From Home
- Unpaid
Adolescent and Young Adults with SCN8A Randomized trial with placebo or NBI-921352
(IRB#: IRB_00150547)
The purpose of this clinical research study is: to find out if the use of study drug NBI-921352 along with the current therapies you are already receiving can help with the treatment of SCN8A Developmental and Epileptic Encephalopathy Syndrome (SCN8A-DEE) by looking at how it affects things such as your symptoms, quality of life, severity of seizures and frequency of seizures. to assess the pharmacokinetics (how the body absorbs, distributes, and gets rid of the study drug of NBI-921352 and to determine its effect on the plasma levels of concomitant (other) antiseizure medications and evaluated metabolites. to evaluate the safety and tolerability of NBI-921352.
- All genders
- Over 7 years old
- Volunteers with special conditions
- In Person
- Paid
Advance Care Planning in Dementia
(IRB#: IRB_00132042)
Advanced care planning is important for adults, but maybe even more for people with memory loss. This disease can leave end-of-life decision-making up to the care partner. Often, the care partner does not know how to make the best decisions in the situation. Research is needed to improve and evaluate a website called LEAD Intervention (Life-Planning in Early Alzheimers and Dementia). LEAD is designed to help persons with memory loss have conversations, document, and share their end-of-life decisions with a care partner, extended family, and healthcare providers.
- All genders
- Over 18 years old
- Healthy Volunteers
- From Home
- Paid
Assessing the Presentation and Symptom Burden of Postural Orthostatic Tachycardia Syndrome (POTS)
(IRB#: IRB_00137161)
Postural Orthostatic Tachycardia Syndrome (POTS) is a blood circulation disorder. This study wants to learn more about how to help people with diagnosed POTS or suspected POTS. People in this study will complete surveys. Participation can last about 60 minutes or less. Surveys can be completed using a paper copy at home, electronically, and in person at a clinic visit.
- All genders
- Over 7 years old
- Healthy Volunteers
- From Home
- Unpaid
Barriers to Low Back Pain Healthcare for People who are Underserved
(IRB#: IRB_00156672)
Low back pain can require imaging (taking a picture) and other medical needs of the lumbar, (lower part of the back). People may have issues attending appointments for their lower back pain. These include language and translation services and lack of health insurance. The study wants to learn how to better help people attend their appointments for low back pain. Being in the study requires completing a survey. The questions may ask about needing an interpreter, health insurance, childcare, or transportation. People who need health insurance or an interpreter will be given help to attend the appointment. The study team will gather data to learn how to better help participants attend doctor appointments. Information collected will not identify the persons name, address, or phone number.
- All genders
- Over 18 years old
- Volunteers with special conditions
- From Home
- Unpaid
Brain Changes with Chronic Pain and Chronic Pain Recovery
(IRB#: IRB_00172536)
Chronic pain is persistent pain in the body. This study wants to learn how people with chronic pain relate to pain and how it impacts the brain. This study also wants to learn whether brain changes will be restored during chronic pain recovery. The knowledge learned will help doctors better understand how to prevent and treat chronic pain issues. People in the study will be in 3 groups. Healthy participants who have never experienced chronic pain. Participants currently experiencing chronic pain. Participants who have recovered from chronic pain. Being in the study requires about 2 visits to the study clinic. Compensation will be given for participation. Medical tests will be done to track the health of participants.
- All genders
- Over 18 years old
- Healthy Volunteers
- In Person
- Paid
Brain Recordings for People with Deep Brain Stimulation for Severe Obsessive-Compulsive Disorder
(IRB#: IRB_00169174)
Obsessive-Compulsive Disorder causes a person to have constant thoughts that can lead to repeated behaviors that may severely disrupt a persons life. This study will look at the effects of deep brain electrical stimulation therapy (small electrodes implanted in a persons brain that send mild amounts of electricity) on a patient with this disorder who has already been implanted with the Deep Brain Stimulation system. The study aims to better understand the relationship between brain activity, behavior, and Obsessive-Compulsive Disorder symptoms to help people with this disorder. People in this study will have the already recorded brain activity they received as standard of care collected and analyzed. Being in the study may last as long as the participant receives stimulation therapy and wants to participate.
- All genders
- Over 18 years old
- Volunteers with special conditions
- In Person
- Unpaid
CAP-1002: A Study Drug for Human Allogeneic Cardioshere-Derived Cells for People with Duchenne Muscular Dystrophy (DMD)
(IRB#: IRB_00150933)
Duchenne Muscular Dystrophy (DMD) is a disease that weakens people's muscles over time. CAP-1002 is a study drug to help people with this disease. Research is needed to learn the safety and effectiveness of the drug. This information we gain may aid future patients.
- Male Only
- Over 7 years old
- Volunteers with special conditions
- In Person
- Paid
Caracterizar la variabilidad en el funcionamiento ejecutivo y diario en adultos hispanos y latinos mayores (Characterizing Variability in Executive and Daily Functioning in Hispanic and Latino/a/e Older Adults)
(IRB#: IRB_00166063)
Estamos analizando las relaciones entre las habilidades de pensamiento y funcionamiento cotidiano en adultos de habla hispana quienes tienen de 50 años en adelante. Estamos observando el impacto de varios factores diarios, tal como el estado de ánimo, sueño y dolor en la habilidad de pensar y completar tareas todos los días. El estudio implicaría venir a la Universidad de Utah para una consulta de investigación de 4 horas y luego hacer tareas diarias en su casa por las siguientes 3 semanas. ¡Le pagaremos su participación! No tiene que tener número de seguro social para participar. Comuníquese con nosotros para más información si está interesado y cumple con el criterio del estudio. (We are examining the relationship between thinking skills and daily functioning in Spanish-speaking adults who are 50 and older. We are looking at the impact of many daily life factors, such as mood, sleep, and pain, on your ability to think and get tasks done each day. The study will involve coming to the University of Utah for a 4-hour research visit and then doing daily tasks at home for the following 3 weeks. We will pay you for your participation! You do not need to have a social security number to participate. Please contact us for more information if you are interested and meet the study criteria.)
- All genders
- Over 18 years old
- Healthy Volunteers
- In Person
- Paid
Chronic Non-Cancer pain MRI research study evaluating the effects of oral cannabis on chronic pain
(IRB#: IRB_00103451)
The purpose of the study is to evaluate the effects of two substances derived from cannabis (THC and CBD) in participants with chronic non-cancer pain compared with a placebo. The study drug will be administered as an extract mixed in chocolate pudding. Participants will be allowed to stay on their current pain treatments for the study but may not add any more medications during the study. Participation in this study will be confidential. This study has been approved by the FDA, DEA, and University of Utah IRB.
- All genders
- Over 18 years old
- Volunteers with special conditions
- In Person
- Paid
Continuous Glucose Monitoring in Adults with Diabetes and Cognitive Impairment or Dementia and Their Care Partners
(IRB#: IRB_00172781)
Continuous Glucose Monitoring is a way to show people with diabetes when they have high or low blood sugar throughout the day. Continuous Glucose Monitoring data can be shared continuously with care partners (family or friends) using an app. However, the person with diabetes and their care partner may need help communicating and problem-solving using the sugar data. This study will explore how to change a current program that uses this data-sharing app. The new program will help older adults with diabetes and cognitive impairment (hard to remember or learn new things), or dementia (memory loss) and their care partners share Continuous Glucose Monitoring data. People in the study will complete a survey and attend a 30-to-90-minute discussion with about 5 to 8 other people to give researchers advice on how to change a current Continuous Glucose Monitoring program. People will be paid for participating.
- All genders
- Over 18 years old
- Volunteers with special conditions
- From Home
- Paid
Couples, healthy aging, rhythms and sleep study (CHARMS)
(IRB#: IRB_00158095)
As people get older they are more likely to have changes to their bodys rhythms, like waking up too early or in the middle of the night. As people get older, their sleep quality also goes down. We also know that sleep in one partner can affect the sleep of the other. Research is showing that having regular sleep/wake rhythms and good quality sleep can help your memory as you get older. The goal of this study is to understand how sleep in couples affects each others sleep and memory over a 2-year period.
- All genders
- Over 18 years old
- Healthy Volunteers
- From Home
- Paid
CVL- 865: A study drug for people with drug-resistant Focal Onset Seizures
(IRB#: IRB_00166301)
This study is open to participants who were in the previous seizure trial numbered CVL-865-SZ-001. This study will give these previous participants open-label treatment with the study drug for 57 weeks. The study drug is called CVL- 865.
- All genders
- Over 18 years old
- Volunteers with special conditions
- In Person
- Paid
Delayed Orthostatic Hypotension in Individuals with Parkinson's Disease
(IRB#: IRB_00170338)
A persons autonomic nervous system is the part of the nervous system that controls involuntary actions, such as the beating of your heart and the widening or narrowing of the blood vessels. Parkinson's disease can cause dysfunction of the autonomic nervous system causing orthostatic hypotension which is a form of low blood pressure that happens when you stand up from sitting or lying down. Orthostatic hypotension can make a person feel dizzy or lightheaded and may even cause fainting. Delayed orthostatic hypotension describes a drop of blood pressure happening beyond 3 minutes of standing. The purpose of this study is to learn the frequency and risk factors of delayed orthostatic hypotension in people with Parkinsons disease. The information will help clinicians be better aware of providing care to patients with delayed Orthostatic hypotension. People in the study will have their blood pressure and heart rate measured. There will be only one 20-minute study visit to measure these.
- All genders
- Over 18 years old
- Volunteers with special conditions
- In Person
- Unpaid
Elucidating Brainstem Contributions to Visceral and Somatic Motor Dysfunction after mTBI
(IRB#: IRB_00135817)
Optimal rehabilitative care following mild traumatic brain injury (mTBI) should be based on approaches that target the key underlying mechanism of dysfunction. However, the underpinnings of motor problems after mTBI, including imbalance and improper regulation of heart rate and blood pressure, remain unclear. This project will use state-of-the-art neuroimaging methods and detailed testing of motor function to examine the role of the brainstem in motor problems to better guide care in people with mTBI. Participants will have an MRI brain scan and complete several tests of mobility, cardiovascular, and pupillary function at two visits, separated three months apart.
- All genders
- Over 18 years old
- Healthy Volunteers
- In Person
- Paid
Evaluation of Sensory Tricks in Individuals with Laryngeal Dystonia or Essential Vocal Tremor
(IRB#: IRB_00130977)
Laryngeal dystonia (LD) is a rare neurogenic voice disorder that results in an intermittently strained-strangled or breathy voice quality during speaking. Essential tremor of the voice (ETv) is another neurogenic voice disorder typically perceived as a shaky voice quality but sometimes associated with a similar voice quality to LD, making it challenging for clinicians to distinguish these voice disorders. A correct diagnosis is essential for accurate and effective treatment of these voice disorders. However, clinical voice experts often confuse these disorders and frequently disagree with each other when judging voice quality or observing speech structures. Development of clinical tools that help clinicians make the correct diagnosis of these disorders is a priority. Therefore, we propose studying a characteristic of dystonias, sensory tricks. A sensory trick is a phenomenon diagnostic of dystonias described as a short-term improvement of symptoms due to sensory cues like touching or supporting a body part or being distracted by a sound. This phenomenon is well studied in other kinds of dystonia but has not been systematically evaluated in LD. This pilot study aims to evaluate whether sensory tricks improve voice symptoms in those with LD compared to those with ETv. If successful, outcomes will help identify specific sensory trick(s) that most clearly change LD symptoms and show promise for improving correct diagnosis of those with LD. The sensory tricks studied should be accessible and affordable for use during assessment by clinicians to help distinguish those with LD from ETv. Importantly, findings will inform future studies to improve utilization by clinicians.
- All genders
- Over 18 years old
- Healthy Volunteers
- In Person
- Paid
Exercise and Brain Function
(IRB#: IRB_00152596)
Exercise is known for helping a persons brain function. Research is needed to better understand how exercise may help improve the brain's learning and memory processes. The information we gain may aid future patients.
- Male Only
- Over 18 years old
- Healthy Volunteers
- In Person
- Paid
Hair Chemicals in Children with Autism Spectrum Disorder
(IRB#: IRB_00153961)
Chemicals applied to a childs hair may impact health outcomes, especially for children with an autism spectrum disorder. Research is needed to learn how chemicals in these children's hair such as zinc, copper, and lead affect health. We also want to know if finding these chemicals in hair is a way to detect autism disorder sooner. The information we gain may aid future patients.
- All genders
- Under 7 years old
- Volunteers with special conditions
- From Home
- Paid
HEALEY ALS Trial
(IRB#: IRB_00143448)
This study is looking at the safety and effectiveness of four different investigational treatment regimens: Zilucoplan, Verdiperstat, CNM-Au8, and Pridopidine for ALS. Each regimen will have an active investigational product and a matching placebo that will be tested. New regimens will be continuously added as new investigational products become available.
- All genders
- Over 18 years old
- Volunteers with special conditions
- In Person
- Paid
Health and Safety Consequences of Poor Sleep Health
(IRB#: IRB_00133959)
Sleep is a key factor affecting your overall health. We want to investigate if altering your nightly sleep duration impacts your bodys metabolism (how you metabolize food). We will also look at your physical activity, food intake, and cognition during the study.
- All genders
- Over 18 years old
- Healthy Volunteers
- In Person
- Paid
Home- and Community-Based Services for Veterans with Cognitive Impairments and their Caregivers
(IRB#: IRB_00152365)
Veterans are at a high risk of having Alzheimer's disease and related dementias (AD/ADRD). This is because of military experiences like traumatic brain injury (TBI) and post-traumatic stress disorder (PTSD). Family members often provide care for Veterans with AD/ADRD. This allows them to live at home in their community. Research is needed to learn about these Veterans and caregivers' current needs and the best home- and community-based care services. The information we gain may aid future patients.
- All genders
- Over 18 years old
- Volunteers with special conditions
- From Home
- Paid
How does brain function change during a treatment cycle of Botox injections for the voice disorder adductor laryngeal dystonia?
(IRB#: IRB_00143531)
The purpose of this study is to find the locations in the brain that are affected by Botox injections into the throat muscles in patients who have adductor-type laryngeal dystonia (also known as adductor spasmodic dysphonia). Participation in this study involves brain scans along with assessments of the voice muscles. Brain scans involve 1) laying still in a scanner while resting and speaking and 2) wearing a head cap while seated and reclined during speaking tasks. Assessment of voice muscles involves small needles inserted into muscles in the voice box. All procedures are well-tolerated by most people. Participants with laryngeal dystonia will have 4 brain scans (2 of each kind) and 2 voice muscle assessments over 1 Botox cycle (approximately 3-4 months). A second purpose of this study is to evaluate a specialized speech therapy program for treating laryngeal dystonia. Therapy will take place over 6 months (2 Botox cycles) and will incorporate in-person or virtual session along with home practice. Some participants may be eligible to participate by completing only some portions of the study.
- All genders
- Over 18 years old
- Volunteers with special conditions
- In Person
- Paid
Improve Technology to Rehabilitate People with Non-Mobility and Mobility Impairment
(IRB#: IRB_00160259)
Smart Technology may be used to help rehabilitate people from injuries. Technology can measure a persons movements such as how they walk. There is a new technology that might reduce the cost and amount of time required to recover from an injury. Research is needed to see if the new technology improves rehabilitation for adults with non-mobility and mobility.
- All genders
- Over 18 years old
- Healthy Volunteers
- In Person
- Paid
Improving Assessment of Executive Functioning in Culturally Diverse Older Adults
(IRB#: IRB_00145891)
Neuropsychological evaluations are often used to help doctors determine how well an individual can live independently. However, many of the tests neuropsychologists use were developed on non-Hispanic White individuals and are not as accurate in culturally diverse individuals. The goal of this study is to determine which measures are best for assessing functioning in culturally-diverse individuals so that neuropsychologists have a better understanding of how improve the accuracy of their assessments.
- All genders
- Over 18 years old
- Healthy Volunteers
- In Person
- Paid
Improving Dementia Care with Hispanic/Latino Communities
(IRB#: IRB_00177351)
Dementia is a disease that affects a persons memory, behavior, and movement. This study will co-design a Spanish-language advanced care planning (ACP) intervention for Hispanic/Latino people living with dementia and their care partners. The study will then test the impact of the intervention on Spanish-speaking Hispanic/Latino people living with Alzheimer's disease or related dementias. The participants who co-design the intervention will meet in groups on Zoom (a way to meet using technology such as a computer). Being in this part of the study requires meeting about 8 times over about 3 years. The study will then test the co-designed Spanish/Latino Alzheimer's disease or related dementia intervention with the specific population.
- All genders
- Over 18 years old
- Healthy Volunteers
- From Home
- Paid
IONIS: A Study Drug to Improve Symptoms of FUS-ALS Patients
(IRB#: IRB_00144685)
IONIS is a potential drug to reduce the body's production of the FUS protein that may contribute to ALS. Scientists and doctors need to learn the effectiveness, safety, tolerability, and breakdown of this medication to improve the symptoms of people with ALS.
- All genders
- Over 7 years old
- Volunteers with special conditions
- In Person
- Paid
Laser Evoked Potentials (LEP) in Patients with Low Back Pain and Healthy Volunteers
(IRB#: IRB_00158608)
People with low back pain may need testing for diagnoses and treatment evaluations. Research is needed to assess if more quantitative measures such as laser evoked potential (LEP) and quantitative sensory testing can be used to tease out differences in patients with low back pain problems and better determine the treatment outcomes. The information we gain may aid future patients.
- All genders
- Over 18 years old
- Healthy Volunteers
- In Person
- Paid
Learning and Memory
(IRB#: IRB_00155080)
Building new memories is known to be a long process. However, studies do show new information can be gained quicker if combined with previous knowledge. Research is needed to learn if young healthy adults build memory faster by attaching present experiences with the past. The information we learn may aid future patients.
- All genders
- Over 18 years old
- Healthy Volunteers
- In Person
- Paid
Magnetic Resonance Imaging (MRI) in Atherosclerotic Disease of the Carotid Artery
(IRB#: IRB_00143315)
Atherosclerotic Disease is a buildup of fat, cholesterol, and other substances on artery walls. An MRI is a way to see places that may have buildup. Research is needed to improve the way an MRI automatically and accurately sees inside the artery walls. The information we gain may aid future patients.
- All genders
- Over 18 years old
- Healthy Volunteers
- In Person
- Paid
Measuring Language Between People with Aphasia and Neurotypical Adults
(IRB#: IRB_00149485)
The study's purpose is to measure event-related potentials (ERPs) of people with aphasia or neurotypical adults. Aphasia is when a person may be unable to speak well after a brain injury such as a stroke and head trauma. Neurotypical is when a person has standard brain functions such as the ability to speak or write without much effort. An ERP is a brain response to when a person may feel, think, speak, write, and move. An ERP is measured through an electromagnetic encephalogram (EEG). An EEG is a cap worn on top of the head with electrodes attached to the cap. The electrodes are a safe way to allow a small amount of electricity to measure a persons brain activity. Participants will read sentences while having their brain activity measured with an EEG. This study will help us better understand language challenges and develop effective ways of language recovery for people with aphasia. Participants will receive $10 an hour for in-person participation at a University of Utah clinic or online using a computer or phone.
- All genders
- Over 18 years old
- Healthy Volunteers
- In Person
- Paid
Migraine Progression and Prevention
(IRB#: IRB_00161605)
Migraines progress becoming more severe or frequent. Research is needed to study if the sensitivity to a persons environment such as light, touch, and sound can cause migraine progression. We hope to understand what makes migraine progress from not often to almost a daily problem. The information we gain may help us create better ways for people to prevent chronic migraine.
- All genders
- Over 18 years old
- Volunteers with special conditions
- In Person
- Paid
Multiple Sclerosis (MS), Autoimmune Diseases, and Infection
(IRB#: IRB_00047316)
The cause of Multiple sclerosis (MS) and autoimmune diseases is unknown. The effects of these can severely hurt a persons brain, spinal cord, and body. We want to understand how infections may relate to the diseases. The information we learn can aid future patients.
- All genders
- Over 18 years old
- Volunteers with special conditions
- In Person
- Paid
NERVE TRANSFERS TO IMPROVE UPPER EXTREMITY FUNCTION AND QUALITY OF LIFE IN TETRAPLEGIC PATIENTS
(IRB#: IRB_00126462)
The purpose of this study is to gather information about the treatment of Spinal Cord Injury (SCI) through the use of a surgical procedure known as a nerve transfer. SCI is a devastating condition which is thought to affect nearly 40 cases per million persons annually in the US. More than 50% SCI occur in the cervical spine (i.e., tetraplegia), resulting in some loss of arm and/or hand function. Nerve transfers are used to improve upper extremity and hand function in patients who have suffered from SCI. This is a treatment option that is available to all (appropriate) patients, and participation in this study is not necessary to receive this treatment. Participation in this study is voluntary, and is available only to those who meet certain eligibility criteria. These criteria will be reviewed on a case by case basis by the University of Utah Department of Neurosurgery's study team as potential participants express their interest in the study. Various appointments and/or diagnostic procedures may be scheduled in order to ensure the eligibility of potential patients. There is no financial cost to patients (aside from the standard costs of care) who participate in this study, and there are no direct financial benefits provided for doing so. Participants will be followed after the procedure both by the surgeon and the physical therapy team. This study does provide funding for the physical therapy services utilized in the long-term follow up phase, but this funding is limited. So participants are encouraged to schedule these visits appropriately. The information provided on this page is not exhaustive, so those who are interested in this study are encouraged to contact our study team to discuss any questions they might have. You can do this by contacting the study coordinator, Kirby Taylor, via telephone or email.
- All genders
- Over 18 years old
- Healthy Volunteers
- In Person
- Paid
New Magnetic Resonance Imaging (MRI) Software to Improve Diagnosis of People with Neurovascular Diseases.
(IRB#: IRB_00162281)
Magnetic Resonance Imaging (MRI) is a way to form pictures inside of a persons body. A new MRI software has been designed to improve the quality and diagnosis of neurovascular diseases in the brain and surrounding areas. These diseases can cause problems in the muscles and nerves of a persons body. We want to learn if new MRI software creates better pictures to help people with neurovascular diseases. The information we gain may aid future patients.
- All genders
- Over 18 years old
- Healthy Volunteers
- In Person
- Paid
Online Psychology Studies
(IRB#: IRB_00175849)
We want to learn how different people behave in complex situations. These complex situations are about how you make choices and what affects your choices. We will ask people in this study to do tasks on a private, online site that we created. We will compare this to how people with epilepsy do the tasks. We hope to better understand how to help people with epilepsy.
- All genders
- Over 18 years old
- Healthy Volunteers
- From Home
- Paid
Patients After a Stroke who Have Weakness in Either Arms or Legs
(IRB#: IRB_00169101)
Paresis can occur after a person has a stroke causing weakness in either the arms or legs. People who have paresis are at risk of having spasticity. This is when the muscles stiffen or tighten without control and can cause pain. The study wants to see what patients 12 months after the first stroke have spasticity. Participants in the study will complete surveys by phone or online (such as using a computer) and attend in-person study visits. If allowed, the study visits may happen at home. The amount of time spent in the study varies and can last up to 18 months after the first stroke. Participants will be paid for being in the study. Medical information will be collected to track the health of participants.
- All genders
- Over 18 years old
- Volunteers with special conditions
- In Person
- Paid
Realize Trial for Drug resistant focal onset seizures
(IRB#: IRB_00130130)
In this study, doctors want to find out if an investigational drug called CVL-865 is effective in decreasing the number of focal onset seizures, also known as partial seizures, without causing too many side effects.
- All genders
- Over 18 years old
- Volunteers with special conditions
- In Person
- Paid
Reflexes and Electrical Stimulation after Neurological Injury
(IRB#: IRB_00167330)
The purpose of this study is to learn how reflexes (a muscle reaction in the body) change in the lower back after neurological (the body's nervous system) injuries such as stroke, spinal cord injury, or leg amputation using non-invasive electrical stimulation (a small pad placed on the skin outside of the body that sends electricity to a muscle). We want to learn how and what a person feels from the stimulation and if it helps improve stability during standing and walking. We also want to learn if there are changes in pain, quality of life, and spasms (a sudden muscle movement in the body) after receiving this stimulation. People in this study will be placed into two groups based on their condition. Group 1 is people who have had a transtibial (below knee) amputation. Group 2 is people with chronic transtibial (below the knee) amputation pain, stroke, or spinal cord injury affecting at least one leg for at least 6 months before participation. Being in the study requires up to 9 weeks and 4 study visits. Each visit will last up to 6 hours depending on what needs to occur at the visit. Medical tests will be done during the study to track the health of participants. Participants will be paid $75 for participation.
- All genders
- Over 18 years old
- Volunteers with special conditions
- In Person
- Paid
Registry for Adenomas of the PItuitary and related Disorders (RAPID)
(IRB#: IRB_00144784)
This study is a surgical registry for patients who undergo surgical resection of pituitary adenomas. The registry allows surgeons and researchers to obtain more accurate data from patients because it is prospective, meaning it data is entered as the patient is treated. One problem with all prior studies is that patient charts are reviewed after treatment which can result in inaccurate data and bias. Clinical data such as visual function, endocrinology function, surgery time, and length of stay will be acquired in addition to other variables. Samples of removed tumor will be stored in the Huntsman Tumor Biobank. Patients will also be provided quality-of-life surveys, brief evaluations done at the time of clinic follow-up or by email, that allows surgeons to better understand how surgical treatment is helping their patients' life at home, ability to reenter the workplace, etc.The purpose of this study is to evaluate best practices, improve the accuracy of epidemiology information, and improve patient outcomes. This registry is part of a multicenter study where the top centers of excellence in the treatment of pituitary adenoma are collaborating to study their data together. Future plans for the registry are to expand to other types of skull base tumors to better understand patient treatment and improve outcomes.
- All genders
- Over 18 years old
- Volunteers with special conditions
- From Home
- Unpaid
Relationship between Pupillary Function, Olfaction, Balance, and Cognition in People with Parkinsons Disease and Essential Tremor
(IRB#: IRB_00158420)
The purpose of the study is to use simple tools that could be used in a health clinic to identify people with Parkinson's disease and essential tremor. People with these health issues are at risk of falling or having dementia. We want to explore the relationship between the pupillary light reflex (the way the pupil constricts when exposed to light) and olfaction (smell) with balance and cognition in people with Parkinson's disease and essential tremor.
- All genders
- Over 18 years old
- Volunteers with special conditions
- In Person
- Unpaid
Rozanolixizumab: A Study Drug for People with Myelin Oligodendrocyte Glycoprotein (MOG) antibody associated disease (MOG-AD)
(IRB#: IRB_00148171)
Myelin Oligodendrocyte Glycoprotein (MOG) antibody-associated disease (MOG-AD) may inflame a persons central nervous system severely affecting nerves in the eyes, brain, and spinal cord. Rozanolixizumab is a study drug to help people with MOG-AD. Research is needed to learn the safety and effectiveness of the study drug. The information we gain may aid future patients.
- All genders
- Over 18 years old
- Volunteers with special conditions
- In Person
- Paid
Safety and Therapeutic Monitoring of Brain Stimulation in Patients with Partial Epilepsy
(IRB#: IRB_00146095)
The purpose of this research is to learn more about 10 daily sessions of transcranial direct current stimulation (tDCS) and see if it can help to reduce the frequency of seizures (the number of seizures in a given period of time) in both adults and children with refractory focal epilepsy (epilepsy that cannot be well controlled by seizure medication). The University of Utah anticipates enrolling five patients in this study.
- All genders
- Over 18 years old
- Volunteers with special conditions
- In Person
- Paid
Staccato Alprazolam: A Study Drug and Device for People with Stereotypical Prolonged Seizures
(IRB#: IRB_00154360)
Seizure emergencies can be long-lasting and hard to control with serious results. Typically, these seizures require drugs to help stop them from happening. Staccato Alprazolam is a new drug and tool combined to help stop this seizure. Research is needed to know the safety and effectiveness of this treatment. The information we learn may aid future patients.
- All genders
- Over 18 years old
- Volunteers with special conditions
- In Person
- Paid
Staccato Alprazolam: A Study Drug for People with Stereotypical Prolonged Seizures
(IRB#: IRB_00148186)
Seizures can be long-lasting and hard to control with serious results. Typically, these seizures require drugs to stop them from happening. Staccato Alprazolam is a new drug to stop this seizure. Research is needed to know the safety and effectiveness of this drug in people who have had prolonged seizures. The information we learn may aid future patients.
- All genders
- Over 18 years old
- Volunteers with special conditions
- In Person
- Paid
Study in Parkinson Disease of Exercise
(IRB#: IRB_00136463)
This study seeks to determine if aerobic exercise influences the progression of Parkinson Disease severity. Based on previous research, we believe that aerobic exercise may protect the brain cells from being damaged and this study hopes to provide more specific evidence regarding this potential benefit.
- All genders
- Over 18 years old
- Volunteers with special conditions
- In Person
- Paid
Study Voice Tremor in People Treated with Focused Ultrasound for Essential Tremor
(IRB#: IRB_00164533)
Essential tremor is when a part of a persons body such as a hand or arm is unsteady or shaky. Vocal tremor is when people may experience an unsteady or shaky voice. This condition may impact the mouth and throat muscles. This study will test whether people receiving focused ultrasound for treatment of essential tremors show improved voice tremors. People in this study will answer questionnaires and be observed for tremor in the face, jaw, tongue, and throat as well as using audio recordings and participant self-reporting. For those who are willing, the study will also examine the speech structures affected by tremors using nasoendoscopy (a procedure to look inside the throat and nose). Participation in the study requires some visits to a study clinic and completion of other activities will be done over the phone and online to track the health of participants.
- All genders
- Over 18 years old
- Volunteers with special conditions
- In Person
- Unpaid
Studying Brain Fog and other Cognitive Dysfunction Symptoms for People with Long COVID
(IRB#: IRB_00168634)
Post-Acute Sequelae of SARS-CoV-2 (PASC) is also known as Long Covid. This study will test three interventions for "brain fog" or cognitive dysfunction that has happened because of infection with COVID. Brain fog may cause confusion, forgetfulness, and lack of focus and mental clarity. The study wants to learn more about interventions to help people with this condition. People in the study will be randomly chosen to receive two treatment interventions delivered online to participants home technology device. People in this study will visit a clinic 3 times to complete surveys, lab tests, and brain function tests. They will also complete brain training sessions at home for 10 weeks and answer follow-up questions about their health and well-being. Participation in this study should last about 6 months. Compensation is provided for participation.
- All genders
- Volunteers with special conditions
- In Person
- Unpaid
Testing a Person's Mobility
(IRB#: IRB_00171076)
This study wants to learn more about how people who either have no neurological (brain) injuries or who have had a stroke move around on different surfaces. These include stairs and uneven ground. The study wants to improve how a person moves with challenges such as a stroke survivor. People in the study will walk on different surfaces such as slopes, stairs, and uneven ground. While walking, information will be recorded from several sensors placed across the body (on the legs, in shoes, on wrist or around the chest). These sensors help collect how participants' muscles work, how they move, and how their heart rate changes as they walk on different surfaces. Being in the study requires attending at least one in-person session that will last up to 3.5 hours. People are paid for participation.
- All genders
- Over 18 years old
- Healthy Volunteers
- In Person
- Paid
Testing the Drug Ubrogepant in Adults and Young Adults with Migraine
(IRB#: IRB_00149183)
Migraine is a reoccurring headache that varies in pain and can cause other health issues such as sick to the stomach, and sensitivity to light and sound. The study will test a drug called Ubrogepant to treat people with the disease. The study wants to see if the drug will help people with the disease and is safe. People in this study will be randomly treated with the Ubrogepant or a placebo. The drug and placebo are swallowed as a pill. This placebo does not have the treatment. Participation in the study is about 6-7 months. Medical tests will be done in-person, on the phone, and online such as using a computer during the study to track the health of participants.
- All genders
- Under 18 years old
- Volunteers with special conditions
- In Person
- Paid
Testing the drug XEN1101 in adults with epilepsy
(IRB#: IRB_00164793)
This study will test a new study drug called XEN1101 to help patients with epilepsy. Epilepsy is a disease that may occur due to a genetic disorder or brain injury. This condition affects the nerves in the brain causing seizures. The study wants to see if XEN110 will help people with the disease and is safe. People in this study will all receive XEN1101 once a day. The drug is taken as a swallowed pill. Being in the study requires regular clinic visits for about 8 months during participation. Medical tests will be done during the study to track the health of participants.
- All genders
- Over 18 years old
- Volunteers with special conditions
- In Person
- Paid
Testing the Timing of Tics Over Time in Children with Persistent Tic Disorders, Including Tourette Syndrome
(IRB#: IRB_00171031)
This is a study is to learn the timing of tics over time in children with Persistent tic disorders, including Tourette syndrome. These conditions are brain disorders that cause uncontrolled body movements and sounds. This behavior may improve and worsen depending on what happens to a person throughout a lifetime. Being in the study requires a child and their parent to attend 6 private video visits using a computer with internet. Visits will include interviews, surveys, learning activities, and training. Participation in the study lasts about 7 hours. All visits will be video recorded and kept in a secure place.
- All genders
- Over 7 years old
- Volunteers with special conditions
- From Home
- Unpaid
Testing the Use of Ultrasound Waves for Adults with Chronic Pain
(IRB#: IRB_00175546)
An ultrasound is a device used on the outside of a persons body that creates sound waves (vibrations) to see the inside organs. This study tests the use of ultrasound to send waves in a focused area as a low-risk method to help people with chronic pain. This study wants to see if the low-risk method is as effective as a different method. People in the study will complete surveys and participate in an MRI (a device used to create an image of the area studied). Being in the study requires at least 4 study visits at the clinic. Medical tests will be done during the study to track the health of participants.
- All genders
- Over 18 years old
- Volunteers with special conditions
- In Person
- Unpaid
The Attention of Expert Boxers
(IRB#: IRB_00155440)
Making instant decisions is important in a variety of settings, including sports such as boxing. When time is limited, decision-making success is strongly determined by things that influence immediate attention. Research is needed to learn whether expert boxers show better attention skills compared to untrained persons. The information we learn may aid future patients.
- All genders
- Over 18 years old
- Healthy Volunteers
- In Person
- Paid
Transcranial Magnetic Stimulation (TMS) for People with Depression in Multiple Sclerosis (MS)
(IRB#: IRB_00164631)
Multiple sclerosis (MS) is a disease that damages nerve cells in the brain and spinal cord. This can affect a persons physical and mental health. Depression, or major depressive disorder, is common in people with MS and often has a serious impact on quality of life. Depression can be difficult to treat with medications in MS. Transcranial magnetic stimulation (TMS) is a safe and approved treatment for medication in people with depression. Little is known about TMS for people with MS. This study wants to better understand the safety and effectiveness of TMS treatment for depression in MS. Participants will receive standard outpatient TMS treatment for depression. This includes in-person, phone, and online Zoom visits to complete surveys and track the health of participants.
- All genders
- Over 18 years old
- Volunteers with special conditions
- In Person
- Paid
University of Utah Long Covid Registry
(IRB#: IRB_00140978)
Researchers at the University of Utah have established a registry to follow individuals who are experiencing prolonged symptoms after COVID-19 infection. We are interested in following people with "Long Covid" using in depth health surveys and optional blood draws to better understand this condition with the goal of ultimately developing clinical management strategies.
- All genders
- Over 18 years old
- Volunteers with special conditions
- From Home
- Unpaid
Viewing Events
(IRB#: IRB_00170628)
The purpose of this study is to determine what people remember from experiences they have in Virtual Reality. We will ask you demographic questions and about your experience with VR. You will view a fictional park scenario presented through a virtual reality (VR) headset, and we will measure where you look and your physiological responses (e.g., heart rate, perspiration) using non-invasive wearable technology. Then we will ask you about the video. Participation in the study requires one study visit and should last up to an hour. Participants will be compensated for their time.
- All genders
- Over 18 years old
- Healthy Volunteers
- In Person
- Paid
VRDN-001: A Study Drug for People with Thyroid Eye Disease
(IRB#: IRB_00152628)
VRDN-001 is a study drug for people with thyroid eye disease. Research is needed to learn the safety and effectiveness of the study drug. The information we gain may aid future patients
- All genders
- Over 18 years old
- Volunteers with special conditions
- In Person
- Paid
XEN1101 Drug Study for People with Primary Generalized Tonic-Clonic Seizures
(IRB#: IRB_00159508)
The purpose of this research is to learn more about the drug XEN1101 and see if it can help to reduce the frequency of seizures (the number of seizures in a given period of time) in adults with primary generalized tonic-clonic seizures. The University of Utah anticipates enrolling five patients in this study.
- All genders
- Over 18 years old
- Volunteers with special conditions
- In Person
- Paid
ZYN002: A Study for Children and Adolescents with Fragile X Syndrome (FXS)
(IRB#: IRB_00146490)
Fragile X Syndrome (FXS) is when a gene in a persons body stops making protein. This protein is needed for a persons brain development. ZYN002 is a gel put on the skin to help children and adolescents with FXS. Research is needed to learn more about the efficacy and safety of ZYN002. The information we gain may aid future patients.
- All genders
- Under 18 years old
- Volunteers with special conditions
- In Person
- Paid